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Cheap Flights from Des Moines to Knoxville

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      Travellers and cabin class, 1 Adult, Economy

      Compare Des Moines to Knoxville flight deals

      Find the cheapest month or even day of the year to fly to Knoxville

      Book the best Knoxville fare with no extra fees

      Flight deals from Des Moines to Knoxville

      Looking for a cheap last-minute deal or the best return flight from Des Moines Airport to Knoxville Airport? If you want to travel next month, return fares start from $404. Find the lowest prices on one-way and return tickets right here.
      Knoxville.$404 per passenger.Departing Fri, 21 Aug, returning Fri, 28 Aug.Return flight with United.Outbound indirect flight with United, departs from Des Moines on Fri, 21 Aug, arriving in Knoxville.Inbound indirect flight with United, departs from Knoxville on Fri, 28 Aug, arriving in Des Moines.Price includes taxes and charges.From $404, select.
      Knoxville.$405 per passenger.Departing Sat, 19 Sep, returning Tue, 22 Sep.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Sat, 19 Sep, arriving in Knoxville.Inbound indirect flight with Delta, departs from Knoxville on Tue, 22 Sep, arriving in Des Moines.Price includes taxes and charges.From $405, select.
      Knoxville.$552 per passenger.Departing Fri, 16 Oct, returning Tue, 20 Oct.Return flight with United.Outbound indirect flight with United, departs from Des Moines on Fri, 16 Oct, arriving in Knoxville.Inbound indirect flight with United, departs from Knoxville on Tue, 20 Oct, arriving in Des Moines.Price includes taxes and charges.From $552, select.
      Knoxville.$608 per passenger.Departing Fri, 24 Jul, returning Sun, 26 Jul.Return flight with Allegiant Air.Outbound indirect flight with Allegiant Air, departs from Des Moines on Fri, 24 Jul, arriving in Knoxville.Inbound indirect flight with Allegiant Air, departs from Knoxville on Sun, 26 Jul, arriving in Des Moines.Price includes taxes and charges.From $608, select.
      Knoxville.$620 per passenger.Departing Fri, 4 Sep, returning Fri, 23 Oct.Return flight with United.Outbound indirect flight with United, departs from Des Moines on Fri, 4 Sep, arriving in Knoxville.Inbound indirect flight with United, departs from Knoxville on Fri, 23 Oct, arriving in Des Moines.Price includes taxes and charges.From $620, select.

      Find the cheapest month to fly from Des Moines to Knoxville

      We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Des Moines to Knoxville flights are currently cheapest in August.
      Jul
      from $613
      Aug
      from $407
      Sep
      from $408
      Oct
      from $556
      Nov
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      Dec
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      Jan
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      Feb
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      Mar
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      Apr
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      May
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      Jun
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      Des Moines to Knoxville: Alternative routes

      Compare routes from Des Moines to Knoxville below. You may find an airport to fly into that's cheaper, faster, or easier than Knoxville.

      Knoxville

      18km from central Knoxville
      ClosestCheapest
      from $407
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      Des Moines to Knoxville: Flight information

      The things to know before you go.
      Cheapest flight found$404
      Cheapest month to flyAugust

      Finding cheap flights from Des Moines to Knoxville: Frequently asked questions

      The best price we found for a return flight from Des Moines to Knoxville is $404. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
      Currently, there are no airlines that fly direct from Des Moines to Knoxville. But we found flights with one or more stops from $404.
      As of July 2026, there are no flights flying from Des Moines to Knoxville.
      The cheapest month to fly from Des Moines to Knoxville is usually August.
      After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to Knoxville Airport on Friday, 21 August 2026.
      No airlines currently offer direct flights between Des Moines Airport and Knoxville Airport. Most routes have one or more stops.
      We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Knoxville but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

      We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Knoxville is around 40 days in advance, so don’t leave your flight to the last minute.

      Currently, United offers the cheapest flight tickets to Knoxville.

      Flying from Des Moines Airport (DSM) to Knoxville Airport (TYS): what you need to know

      • To ensure you catch your DSM to TYS flight, leave plenty of time for things like check-in and baggage drop. Turning up two hours before international departures and an hour before domestic flights is the standard rule.

      • Flying during a peak time such as August? Public holidays and other popular seasons can lead to longer queues and delays at airport checkpoints. Play it safe and arrive up to four hours ahead of international flights and two hours before a domestic departure.

      • We make it a piece of cake to book a flight with a stopover. To see your options for tickets from Des Moines Airport to Knoxville Airport, deselect 'Direct flights only.' Then, pick a flight that has a stop long enough to explore your chosen city. Popular stopovers between DSM and TYS include:

        • Chicago O'Hare International Airport

        • Atlanta Hartsfield-Jackson Airport

        • Charlotte Douglas Airport

      Handy information about Des Moines Airport (DSM)

      • DSM is located at 5800 Fleur Drive, Suite 201.

      • Of all flights departing from Des Moines Airport, 77% touch down on time at their destination.

      • To reach Des Moines Airport from central Des Moines, it'll take about 15 minutes by car. This depends on traffic, however. It's approximately 11 kilometres from the airport to the city centre.

      • The journey on public transport takes roughly 30 minutes.

      • Need a convenient hotel near DSM? If you're catching an early flight from Des Moines Airport to Knoxville Airport, these stays will have you moments from your check-in counter:

      Arriving at Knoxville Airport (TYS)

      Getting from Knoxville Airport (TYS) to central Knoxville

      • You'll find TYS at 2055 Alcoa Highway.

      • Knoxville Airport to the centre of Knoxville has a drive time of around 25 minutes. It's approximately 24 kilometres away.

      • Travelling on public transport will take you roughly 50 minutes.

      When to fly to Knoxville Airport (TYS)

      • October is the most popular month for flights from Des Moines Airport to Knoxville Airport. To escape the crowds, go to Knoxville in March.

      • Before locking in your flight from Des Moines Airport to Knoxville Airport, consider the type of weather you enjoy. July is the warmest month in Knoxville, with the temperature ranging from 17ºC to 32ºC.

      • January sees average temperatures of between -6ºC and 11ºC. Look for cheap tickets from DSM to TYS sometime around then if you like travelling in cooler conditions.

      Explore more of the United States

      • Knoxville has plenty to offer, but there are so many other corners of the United States you should also see. About 451 kilometres north of Knoxville, a trip to Columbus will fill your itinerary to the brim. Start with attractions like Franklin Park Conservatory and Botanical Gardens, Whetstone Park / Park of Roses and Ohio Theatre.

      • Around 467 kilometres north-west of Knoxville, Indianapolis is another favourite stop in the United States. Experience major highlights starting with Lucas Oil Stadium, Eiteljorg Museum and The Children's Museum of Indianapolis.

      Plan the rest of your trip from Des Moines to Knoxville

      Prices shown on this page are estimated lowest prices only. Found in the last 12 days.