Cheap Flights from Mexico City to Santiago

Return selected

origin

Enter the city you're flying from, or choose from the options below

Include nearby airports

selected

destination

. Enter your destination, or choose from the options below

Include nearby airports

selected

Travellers and cabin class, 1 Adult, Economy

Compare Mexico City to Santiago flight deals

Find the cheapest month or even day of the year to fly to Santiago

Book the best Santiago fare with no extra fees

Flight deals Cheapest month Find the best route Route info FAQs Tips and advice

Flight deals from Mexico City to Santiago

Looking for a cheap last-minute deal or the best return flight from Mexico City to Santiago Airport? If you want to travel next month, return fares start from $779. Find the lowest prices on one-way and return tickets right here.

Santiago.$778 per passenger.Departing Thu, 24 Sep, returning Thu, 1 Oct.Return flight with Copa.Outbound indirect flight with Copa, departs from Mexico City Juarez International on Thu, 24 Sep, arriving in Santiago.Inbound indirect flight with Copa, departs from Santiago on Thu, 1 Oct, arriving in Mexico City Juarez International.Price includes taxes and charges.From $778, select.

Santiago.$778 per passenger.Departing Thu, 1 Oct, returning Thu, 8 Oct.Return flight with Copa.Outbound indirect flight with Copa, departs from Mexico City Juarez International on Thu, 1 Oct, arriving in Santiago.Inbound indirect flight with Copa, departs from Santiago on Thu, 8 Oct, arriving in Mexico City Juarez International.Price includes taxes and charges.From $778, select.

Santiago.$779 per passenger.Departing Sun, 20 Sep, returning Sat, 26 Sep.Return flight with Copa.Outbound indirect flight with Copa, departs from Mexico City Juarez International on Sun, 20 Sep, arriving in Santiago.Inbound indirect flight with Copa, departs from Santiago on Sat, 26 Sep, arriving in Mexico City Juarez International.Price includes taxes and charges.From $779, select.

Santiago.$819 per passenger.Departing Mon, 31 Aug, returning Thu, 3 Sep.Return flight with Copa.Outbound indirect flight with Copa, departs from Mexico City Juarez International on Mon, 31 Aug, arriving in Santiago.Inbound indirect flight with Copa, departs from Santiago on Thu, 3 Sep, arriving in Mexico City Juarez International.Price includes taxes and charges.From $819, select.

Santiago.$823 per passenger.Departing Mon, 8 Mar, returning Mon, 22 Mar.Return flight with Copa.Outbound indirect flight with Copa, departs from Mexico City Juarez International on Mon, 8 Mar, arriving in Santiago.Inbound indirect flight with Copa, departs from Santiago on Mon, 22 Mar, arriving in Mexico City Juarez International.Price includes taxes and charges.From $823, select.

Santiago.$842 per passenger.Departing Fri, 30 Oct, returning Mon, 2 Nov.Return flight with Copa.Outbound indirect flight with Copa, departs from Mexico City Juarez International on Fri, 30 Oct, arriving in Santiago.Inbound indirect flight with Copa, departs from Santiago on Mon, 2 Nov, arriving in Mexico City Juarez International.Price includes taxes and charges.From $842, select.

Santiago.$876 per passenger.Departing Wed, 18 Nov, returning Mon, 23 Nov.Return flight with Copa.Outbound indirect flight with Copa, departs from Mexico City Juarez International on Wed, 18 Nov, arriving in Santiago.Inbound indirect flight with Copa, departs from Santiago on Mon, 23 Nov, arriving in Mexico City Juarez International.Price includes taxes and charges.From $876, select.

Santiago.$893 per passenger.Departing Mon, 15 Feb, returning Thu, 18 Feb.Return flight with Copa.Outbound indirect flight with Copa, departs from Mexico City Juarez International on Mon, 15 Feb, arriving in Santiago.Inbound indirect flight with Copa, departs from Santiago on Thu, 18 Feb, arriving in Mexico City Juarez International.Price includes taxes and charges.From $893, select.

Santiago.$1,036 per passenger.Departing Thu, 24 Dec, returning Mon, 4 Jan.Return flight with Copa.Outbound indirect flight with Copa, departs from Mexico City Juarez International on Thu, 24 Dec, arriving in Santiago.Inbound indirect flight with Copa, departs from Santiago on Mon, 4 Jan, arriving in Mexico City Juarez International.Price includes taxes and charges.From $1,036, select.

Santiago.$2,092 per passenger.Departing Wed, 20 Jan, returning Tue, 26 Jan.Return flight with United.Outbound indirect flight with United, departs from Mexico City Juarez International on Wed, 20 Jan, arriving in Santiago.Inbound indirect flight with United, departs from Santiago on Tue, 26 Jan, arriving in Mexico City Juarez International.Price includes taxes and charges.From $2,092, select.

Santiago.$2,154 per passenger.Departing Tue, 24 Nov, returning Tue, 8 Dec.Return flight with United.Outbound indirect flight with United, departs from Mexico City Juarez International on Tue, 24 Nov, arriving in Santiago.Inbound indirect flight with United, departs from Santiago on Tue, 8 Dec, arriving in Mexico City Juarez International.Price includes taxes and charges.From $2,154, select.

Santiago.$3,204 per passenger.Departing Thu, 17 Dec, returning Sun, 27 Dec.Return flight with United.Outbound indirect flight with United, departs from Mexico City Juarez International on Thu, 17 Dec, arriving in Santiago.Inbound indirect flight with United, departs from Santiago on Sun, 27 Dec, arriving in Mexico City Juarez International.Price includes taxes and charges.From $3,204, select.

Find the cheapest month to fly from Mexico City to Santiago

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Mexico City to Santiago flights are currently cheapest in October.

Aug

Sep

Oct

Nov

Dec

Jan

Feb

Mar

Apr

May

Jun

Jul

Mexico City to Santiago: Alternative routes

Compare routes from Mexico City to Santiago below. You may find an airport to fly into that's cheaper, faster, or easier than Santiago.

Santiago

2km from central Santiago

ClosestCheapest

from $778

Search flights

Puerto Plata

36km from central Santiago

from $813

Search flights

Mexico City to Santiago: Flight information

The things to know before you go.

Cheapest flight found	$778
Cheapest month to fly	September

Finding cheap flights from Mexico City to Santiago: Frequently asked questions

How much are return flights from Mexico City to Santiago?

The best price we found for a return flight from Mexico City to Santiago is $778. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

Which airlines fly direct from Mexico City to Santiago?

Currently, there are no airlines that fly direct from Mexico City to Santiago. But we found flights with one stop from $778.

How many flights are there a week from Mexico City to Santiago?

As of August 2026, there are no flights flying from Mexico City to Santiago.

When is the cheapest time to fly from Mexico City to Santiago?

The cheapest month to fly from Mexico City to Santiago is usually September.

Which upcoming date is cheapest to fly from Mexico City to Santiago Airport on?

After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Mexico City to Santiago Airport on Thursday, 24 September 2026.

Can I get a direct flight from Mexico City to Santiago Airport?

No airlines currently offer direct flights between Mexico City and Santiago Airport. Most routes have one or more stops.

How can I find the best flight deal to Santiago?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Santiago but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Santiago?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Santiago is around 40 days in advance, so don’t leave your flight to the last minute.

Which is the cheapest airline to fly from Mexico City to Santiago with?

The cheapest airline that flies to Santiago is Copa .

Travelling from Mexico City to Cibao International Airport (STI): What you need to know

Cibao International Airport is located in Santiago. The city is in the UTC-4 timezone and is two hours ahead of Mexico City.
Your flight from Mexico City to STI won't wait if you're running late, so get to the airport with time to spare. Arrive up to one hour in advance for domestic flights and two hours ahead for international travel.
Show up at the airport even earlier during popular months like September. Aim for two hours before a domestic departure and as much as four hours for an international flight. After checking in, you can use any extra time to relax or grab something to eat.

Airports in Mexico City

Mexico City Benito Juarez International Airport (MEX)

We make it a piece of cake to book cheap flights from Mexico City to STI that include a stopover. To explore the options departing from Mexico City Benito Juarez International Airport (MEX), uncheck 'Direct flights only.' Next, pick a flight offering a stop long enough to tour your chosen city. Some popular stopovers between MEX and STI include:
- New York John F. Kennedy International Airport (JFK)
- Newark Liberty International Airport (EWR)
- Miami International Airport (MIA)
Located around 13 kilometres from the centre of Mexico City, MEX can be reached in about 30 minutes by car (depending on traffic). The journey on public transport will take roughly 40 minutes.
Have an early flight from Mexico City to Cibao International Airport? Avoid the stress of rushing to the terminal (and enjoy a little extra shut-eye) by choosing one of these hotels close to Mexico City Benito Juarez International Airport:
Mexico City Benito Juarez International Airport has a strong on-time performance, reducing the likelihood of delays. Departures from MEX arrive on schedule 84% of the time.

Mexico City Felipe Angeles International Airport (NLU)

Fit a stopover into your itinerary at Santo Domingo Las Americas International Airport (SDQ). It's a key transfer point for flights from Mexico City to Cibao International Airport (STI) leaving Mexico City Felipe Angeles International Airport.
NLU is about 56 kilometres from central Mexico City. It'll take 55 minutes or so to get to the airport by car from the city centre. Public transport takes roughly 2 hours.
Relax before your Mexico City to STI flight at a hotel close to Mexico City Felipe Angeles International Airport. Verticca Hotel is one option where you can wake up and get to the airport with time to spare.
Mexico City Felipe Angeles International Airport has an on-time performance of 76%. This figure sheds light on how often flights that take off from this airport arrive at their destination on time.

About Cibao International Airport (STI)

Have a late flight from Mexico City to Cibao International Airport? Don't let your travel day stretch into tomorrow. Stay at one of these hotels near STI and hit the pillow fast:
To get the best deal, reserve your ride around one week in advance of your Mexico City to Cibao International Airport flight.

Getting from Cibao International Airport (STI) to central Santiago

Central Santiago is around 16 kilometres from Cibao International Airport and takes about 25 minutes to reach by car. See what your options are for making the trip into the city, whether that's with a car hire, taxi or ride-share.
If you're taking public transport, expect a journey time of roughly 40 minutes.

How to find the cheapest flights from Mexico City to Cibao International Airport (STI)

Currently, $409 is the lowest price we've found for a one-way ticket from Mexico City to Cibao International Airport. The cheapest price for a return flight is $778. Keep in mind fares can change due to demand at the time of booking.
Booking ahead of time is often the key to finding a cheap flight from Mexico City to STI. Fares tend to rise as demand increases, so the closer your departure date, the more you'll likely spend.
Cheap Mexico City to Cibao International Airport tickets are easier to find if you're not locked into specific dates. Try using the 'Whole month' search tool to compare fares throughout the month and then pick the cheapest day.
Locking in a cheap plane ticket from Mexico City to STI couldn't be easier with Price Alerts. All you need to do is set up one of these automatic alerts and we'll let you know when there's a price drop.
Save on your flight from Mexico City to Cibao International Airport by using filters. Select your preferred departure time, duration and airlines, then sort the results by 'Cheapest' for the best deals.

The best time to fly from Mexico City to Cibao International Airport (STI)

It's time to figure out when to book your flight from Mexico City to Cibao International Airport (STI). August is the busiest month to visit Santiago. If you prefer a quieter vibe, think about going in December.
The warmest month in Santiago is August, with temperatures ranging between 21ºC and 33ºC. Book your Mexico City to STI plane ticket then if you enjoy this type of weather.
Look for cheap tickets from Mexico City to Cibao International Airport in January if you like travelling in cooler conditions. Temperatures are at their lowest then, ranging between 16ºC and 29ºC.

More about Santiago

Start your Santiago trip right by choosing the perfect place to stay. After booking your flight from Mexico City to Cibao International Airport, check out our selection of accommodation options including:
All great journeys should include some sightseeing. MTB National Park, Catedral de Santiago Apostol and Monument to the Heroes of the Restoration are must-visits when exploring Santiago.

Explore more of the Dominican Republic

Santiago will leave a lasting impression, but there are so many other corners of the Dominican Republic you should also see. About 129 kilometres southeast of Santiago, a trip to Santo Domingo will fill your itinerary to the brim. Start with attractions like Catedral Primada de las Americas, Alcazar de Colon and The Cathedral of the Americas.
If you're interested in discovering another great destination in the Dominican Republic, consider Santo Domingo Este, about 129 kilometres southeast of Santiago. Lago los tres ojos, National Aquarium and La Cueva del Eden are highlights.