Cheap Flights from Manchester to Knoxville

Compare Manchester to Knoxville flight deals

Find the cheapest month or even day of the year to fly to Knoxville

Book the best Knoxville fare with no extra fees

Flight deals from Manchester to Knoxville

Looking for a cheap last-minute deal or the best return flight from Manchester to Knoxville? Find the lowest prices on one-way and return tickets right here.

Find the cheapest month to fly from Manchester to Knoxville

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Manchester to Knoxville flights are currently cheapest in May.

Manchester to Knoxville: Alternative routes

Compare routes from Manchester to Knoxville below. You may find an airport to fly into that's cheaper, faster, or easier than Knoxville.

Manchester to Knoxville: Flight information

The things to know before you go.
Cheapest flight found$602
Cheapest month to flyMay

Finding cheap flights from Manchester to Knoxville: Frequently asked questions

The best price we found for a return flight from Manchester to Knoxville is $602. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Manchester to Knoxville. But we found flights with one or more stops from $602.
As of February 2026, there are no flights flying from Manchester to Knoxville.
The cheapest month to fly from Manchester to Knoxville is usually May.
After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Manchester Airport to Knoxville Airport on Saturday, 16 May 2026.
No airlines currently offer direct flights between Manchester Airport and Knoxville Airport. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Knoxville but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Knoxville is around 40 days in advance, so don’t leave your flight to the last minute.
Currently, Southwest Airlines offers the cheapest flight tickets to Knoxville.

Travelling from Manchester Boston Regional Airport (MHT) to McGhee Tyson Airport (TYS): what you need to know

  • Arrive at the airport on time so you don't miss your MHT to TYS flight. Be there at least two hours ahead for international flights and an hour early for domestic departures to avoid the stress of rushing.

  • During popular months like August, you'll want to get to the airport earlier than normal. Plan to arrive two hours before domestic departures and four hours ahead for an international flight when you fly during a peak period in general.

  • If you want to explore another city along the way, just deselect 'Direct flights only' when searching for your ticket from Manchester Boston Regional Airport to McGhee Tyson Airport. Here are the top stopovers between MHT and TYS:

    • Philadelphia International Airport

    • Ronald Reagan National Airport

    • Charlotte Douglas International Airport

How to find the cheapest flights from Manchester Boston Regional Airport (MHT) to McGhee Tyson Airport (TYS)

  • $808 is the lowest price for a one-way Manchester Boston Regional Airport to McGhee Tyson Airport flight. A return flight starts from $602. These fares can change depending on demand and availability.

  • It's often best to book in advance if you're hoping to get cheap tickets from MHT to TYS. That's because airlines adjust prices based on demand, which tends to increase closer to departure.

  • The 'Whole month' search function shows you the cheapest flights from Manchester Boston Regional Airport to McGhee Tyson Airport across the month. It's a great way to find a bargain if your travel plans aren't set in stone.

  • Picking up cheap flights from MHT to TYS is a breeze with Price Alerts. All you need to do is create one of these automatic alerts and we'll notify you when a new deal comes up.

  • Choose your ideal arrival and departure times, number of stops and airlines with the filters. Or sort your results by 'Cheapest' to see the best deals on flights from Manchester Boston Regional Airport to McGhee Tyson Airport.

Handy information about Manchester Boston Regional Airport (MHT)

  • You'll find MHT at One Airport Road.

  • Manchester Boston Regional Airport scores top marks for its on-time performance. 81.02% of flights that take off from MHT reach their destination without delay.

  • Central Manchester to Manchester Boston Regional Airport is approximately 10 kilometres. Depending on traffic, it'll take about 20 minutes to get there if you're driving, ride-sharing or catching a cab.

  • Taking public transport? Expect a journey time of around 55 minutes.

  • Catching an early flight from Manchester Boston Regional Airport to McGhee Tyson Airport? Avoid the stress of rushing to the terminal (and sneak in some extra snooze time) by picking one of these hotels close to MHT:

Arriving at McGhee Tyson Airport (TYS)

  • The last thing you want is a lengthy trip to your hotel if you're getting in late on a Manchester Boston Regional Airport to McGhee Tyson Airport flight. Reserve one of these accommodation options near TYS instead:

  • Get on the fast track to adventure by picking up a McGhee Tyson Airport rental car. Grab your wheels from Budget, Alamo or Avis and explore beyond Knoxville's usual tourist stops.

  • Lock in the best possible rate by reserving your ride from McGhee Tyson Airport around three weeks before your travel date.

Getting from McGhee Tyson Airport (TYS) to central Knoxville

  • You'll find TYS at 2055 Alcoa Highway.

  • McGhee Tyson Airport is approximately 23 kilometres from the centre of Knoxville. Driving there takes about 20 minutes.

When to fly to McGhee Tyson Airport (TYS)

  • The quietest month for a flight from Manchester Boston Regional Airport to McGhee Tyson Airport is February, while July is the most popular. Pick the best time to visit Knoxville based on whether you prefer a bustling atmosphere or a more laid-back vibe.

  • The warmest month in Knoxville is July, with the temperature ranging between 17ºC and 32ºC. Book your flights from Manchester Boston Regional Airport to McGhee Tyson Airport in this month if you like this kind of weather.

  • January sees average temperatures of between -6ºC and 11ºC. Look for cheap tickets from MHT to TYS sometime around then if you want to travel in cooler conditions.

Explore more of United States

  • Knoxville is easy to fall in love with, but there are so many other corners of United States you should also see. About 451 kilometres north of Knoxville, a trip to Columbus will fill your itinerary to the brim. Check out popular attractions like Franklin Park Conservatory and Botanical Gardens, Ohio Statehouse and German Village.

  • If you're ready to explore another major stop in United States, head for Indianapolis, about 467 kilometres north-west of Knoxville. The Children's Museum of Indianapolis, Indianapolis Museum of Art and Indianapolis Zoo are the start of reasons to visit.

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.