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Cheap Flights from Panama City to Brussels

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Flight deals from Panama City to Brussels

Looking for a cheap last-minute deal or the best return flight from Panama City to Brussels? Find the lowest prices on one-way and return tickets right here.
Brussels.$1,370 per passenger.Departing Thu, 21 May, returning Thu, 11 Jun.Return flight with Turkish Airlines.Outbound indirect flight with Turkish Airlines, departs from Panama City Tocumen International on Thu, 21 May, arriving in Brussels International.Inbound indirect flight with Turkish Airlines, departs from Brussels International on Thu, 11 Jun, arriving in Panama City Tocumen International.Price includes taxes and charges.From $1,370, select.
Brussels.$1,439 per passenger.Departing Wed, 4 Feb, returning Wed, 11 Feb.Return flight with Turkish Airlines.Outbound indirect flight with Turkish Airlines, departs from Panama City Tocumen International on Wed, 4 Feb, arriving in Brussels International.Inbound indirect flight with Turkish Airlines, departs from Brussels International on Wed, 11 Feb, arriving in Panama City Tocumen International.Price includes taxes and charges.From $1,439, select.
Brussels.$1,537 per passenger.Departing Tue, 3 Nov, returning Tue, 1 Dec.Return flight with Air Europa.Outbound indirect flight with Air Europa, departs from Panama City Tocumen International on Tue, 3 Nov, arriving in Brussels International.Inbound indirect flight with Air Europa, departs from Brussels International on Tue, 1 Dec, arriving in Panama City Tocumen International.Price includes taxes and charges.From $1,537, select.
Brussels.$2,042 per passenger.Departing Sun, 18 Jan, returning Sun, 25 Jan.Return flight with KLM.Outbound indirect flight with KLM, departs from Panama City Tocumen International on Sun, 18 Jan, arriving in Brussels International.Inbound indirect flight with KLM, departs from Brussels International on Sun, 25 Jan, arriving in Panama City Tocumen International.Price includes taxes and charges.From $2,042, select.
Brussels.$2,054 per passenger.Departing Sun, 5 Jul, returning Sun, 19 Jul.Return flight with Iberia.Outbound indirect flight with Iberia, departs from Panama City Tocumen International on Sun, 5 Jul, arriving in Brussels International.Inbound indirect flight with Iberia, departs from Brussels International on Sun, 19 Jul, arriving in Panama City Tocumen International.Price includes taxes and charges.From $2,054, select.
Brussels.$2,250 per passenger.Departing Fri, 26 Dec, returning Fri, 2 Jan.Return flight with KLM.Outbound indirect flight with KLM, departs from Panama City Tocumen International on Fri, 26 Dec, arriving in Brussels International.Inbound indirect flight with KLM, departs from Brussels International on Fri, 2 Jan, arriving in Panama City Tocumen International.Price includes taxes and charges.From $2,250, select.

Find the cheapest month to fly from Panama City to Brussels

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Panama City to Brussels flights are currently cheapest in February.
Dec
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Jan
from $2,042
Feb
from $1,439
Mar
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Apr
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May
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Jun
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Jul
from $2,054
Aug
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Sep
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Oct
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Nov
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Alternative Panama City to Brussels routes

Looking for the cheapest, fastest or easiest route from Panama City to Brussels? You could fly into the following airports instead.

Panama City to Brussels: Flight information

The things to know before you go.
Cheapest flight found$1,373
Cheapest month to flyMay

Finding cheap flights from Panama City to Brussels: Frequently asked questions

There are 5 airports in Brussels: Brussels International, Antwerp Deurne, Brussels S. Charleroi, Liege, and Kortrijk.
The best price we found for a return flight from Panama City to Brussels is $1,370. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
Currently, there are no airlines that fly direct from Panama City to Brussels. But we found flights with one or more stops from $1,370.
As of December 2025, there are no flights flying from Panama City to Brussels.
The cheapest month to fly from Panama City to Brussels is usually May.
If you're flying from Panama City, the cheapest airport near Brussels is Brussels International – which is 11.0 km away from the centre of Brussels. We've found flights into this airport from $1,370.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Panama City to Brussels on Thursday, 21 May 2026.
No airlines currently offer direct flights between Panama City and Brussels. Most routes have one or more stops.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Brussels but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Brussels is around 40 days in advance, so don’t leave your flight to the last minute.
In December, the average temperature is usually around 3°C. July is typically the warmest month in Brussels, when it usually averages around 22°C. You can expect the least rain in April. The coldest month is January, with temperatures averaging -0°C. The rainiest month is December.
The cheapest airline that flies to Brussels is Turkish Airlines .

Flying from Panama City to Brussels: what you need to know

  • Start your travel planning by considering where you'll board your flight from Panama City to Brussels. Tocumen International Airport (PTY) and Panama Pacifico Airport (BLB) are the main airports in Panama City.

  • Brussels Airport (BRU) and Brussels S. Charleroi Airport (CRL) are Brussels's primary gateways.

  • The timezone in Brussels is UTC+1, which is six hours ahead of Panama City.

  • To ensure you make your Panama City to Brussels flight, allow plenty of time to check in and drop off your luggage. Arriving two hours ahead of international departures and one hour before domestic flights is a good rule of thumb.

  • Flying during a peak month such as June? Public holidays and other high seasons can mean longer queues at security. Be extra cautious and arrive up to four hours ahead of international flights and two hours before domestic departures.

How to find the cheapest flights from Panama City to Brussels

  • Booking ahead of time is often the key to locking in a cheap Panama City to Brussels flight. Airlines adjust prices based on demand, so the nearer your departure date, the more you'll likely spend on your ticket.

  • If you're flexible with your travel dates, try using the 'Whole month' tool. It'll show you the cheapest price in every month when looking for your plane ticket from Panama City to Brussels.

  • You don't need to check every day to see if prices have dropped when you set up a Price Alert. We'll tell you as soon as there's a better deal on cheap flights from Panama City to Brussels.

  • Pick your ideal departure and arrival times, airlines and number of stops by using the filters. Alternatively, sort your Panama City to Brussels flight results by 'Fastest,' 'Cheapest' or 'Best.'

Flying from Panama City

Tocumen International Airport (PTY)

  • We make it simple to find a Panama City to Brussels flight with a stopover. To see the options leaving from Tocumen International Airport, deselect 'Direct flights only.' Then, select a flight with a stop long enough to explore your chosen city. Some popular stopovers include:

    • Adolfo Suarez Madrid-Barajas Airport (MAD)

    • Newark Liberty International Airport (EWR)

    • Washington Dulles International Airport (IAD)

  • Located around 18 kilometres from the centre of Panama City, PTY can be reached in about 20 minutes by car (depending on traffic). The journey by public transport is roughly 1 hour 5 minutes.

  • Need a convenient hotel close to Tocumen International Airport? If you're boarding an early flight from Panama City to Brussels, these accommodation options will have you nice and close to your departure gate:

  • 86.03% of flights departing from Tocumen International Airport touch down at their destination according to schedule. Given its strong performance rating, you're unlikely to face delays when flying out of PTY.

Panama Pacifico Airport (BLB)

  • Depending on traffic, you can drive to BLB from central Panama City in around 20 minutes. The airport is roughly 11 kilometres away.

  • Want to treat yourself to an extra night away before catching your flight from Panama City to Brussels? Relax in a hotel near Panama Pacifico Airport before your adventure officially starts. Check out these accommodation options:

  • Most flights that leave Panama Pacifico Airport arrive at their destination as expected. It boasts a strong on-time performance rate of 87%.

Arriving in Brussels

Brussels Airport (BRU)

  • The distance from Brussels Airport (BRU) to central Brussels is roughly 11 kilometres. It takes around 20 minutes to get to the centre driving.

  • It usually takes 40 minutes to get there on public transport.

  • If you're arriving on a late flight from Panama City to Brussels, nothing beats the convenience of staying near the terminal. Grab your bags from the carousel and then be showered and sleeping soon after at one of these hotels near BRU:

  • Pick up a Brussels Airport rental car and discover Brussels and beyond with your own wheels. Keddy By Europcar, Alamo and Europcar are popular outlets you can book with here.

  • Reserving your ride from Brussels Airport about three weeks in advance can help you secure the lowest rate.

Brussels S. Charleroi Airport (CRL)

  • Central Brussels is located around 48 kilometres from Brussels S. Charleroi Airport (CRL). As soon as your flight from Panama City to Brussels has landed and you've made your way through the terminal, the drive should be around 55 minutes.

  • You can expect the trip to take about 1 hour 35 minutes on public transport.

  • There are some great places ready to welcome you near CRL. Kick back after your Panama City to Brussels flight at one of these perfectly located options:

  • The quickest way to reach your destination is with a Brussels S. Charleroi Airport rental car. Collect a set of wheels from Keddy By Europcar, Thrifty or Budget and make a speedy getaway.

  • Get the pick of the lot. Booking your ride from CRL two weeks ahead of time often means lower prices and a greater selection of vehicles.

Best time to go to Brussels

  • January is the quietest month for flights from Panama City to Brussels, while July is the busiest. Find the ideal time to go to Brussels based on whether you like a laid-back vibe or a lively atmosphere.

  • The warmest month in Brussels is August, with temperatures ranging between 12ºC and 27ºC. Lock in your Panama City to Brussels ticket then if you enjoy this type of weather.

  • If you like cooler conditions, look for a cheap flight from Panama City to Brussels in January when temperatures average between -2ºC and 8ºC.

More about Brussels

  • Once you've booked your flight from Panama City to Brussels, choose a hotel that puts you where you want to be. Make one of these options your base for exploring Brussels:

  • There are so many things to explore in this city it can be hard to work out where to begin. Grand Place, Atomium and Manneken Pis are highlights which should feature on any good Brussels itinerary.

Explore more of Belgium

  • Charleroi is just one of the many cities in Belgium waiting to be discovered once you've seen the sights of Brussels. Around 48 kilometres to the south, popular attractions include Parc Gobbe, Maison Dermine (art déco — 1921) and Parc Ligny.

  • If you're interested in discovering another major destination in Belgium, consider Liege, about 88 kilometres east of Brussels. Gare de Liege-Guillemins, Curtius Museum and Montagne de Bueren are the start of reasons to visit.

More travel options

Plan the rest of your trip from Panama City to Brussels

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.