Cheap Flights from San Diego to Panama City

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Compare San Diego to Panama City flight deals

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Flight deals from San Diego to Panama City

Looking for a cheap last-minute deal or the best return flight from San Diego to Panama City? If you want to travel next month, return fares start from $1,168. Find the lowest prices on one-way and return tickets right here.

Panama City.$922 per passenger.Departing Wed, 7 Apr, returning Wed, 14 Apr.Return flight with Copa.Outbound direct flight with Copa departs from San Diego International on Wed, 7 Apr, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Wed, 14 Apr, arriving in San Diego International.Price includes taxes and charges.From $922, select.

Panama City.$928 per passenger.Departing Wed, 11 Nov, returning Sun, 15 Nov.Return flight with Copa.Outbound direct flight with Copa departs from San Diego International on Wed, 11 Nov, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Sun, 15 Nov, arriving in San Diego International.Price includes taxes and charges.From $928, select.

Panama City.$943 per passenger.Departing Wed, 17 Mar, returning Wed, 24 Mar.Return flight with United.Outbound indirect flight with United, departs from San Diego International on Wed, 17 Mar, arriving in Panama City Tocumen International.Inbound indirect flight with United, departs from Panama City Tocumen International on Wed, 24 Mar, arriving in San Diego International.Price includes taxes and charges.From $943, select.

Panama City.$945 per passenger.Departing Mon, 25 Jan, returning Sun, 7 Feb.Return flight with United.Outbound indirect flight with United, departs from San Diego International on Mon, 25 Jan, arriving in Panama City Tocumen International.Inbound indirect flight with United, departs from Panama City Tocumen International on Sun, 7 Feb, arriving in San Diego International.Price includes taxes and charges.From $945, select.

Panama City.$958 per passenger.Departing Mon, 30 Nov, returning Wed, 9 Dec.Return flight with Delta.Outbound indirect flight with Delta, departs from San Diego International on Mon, 30 Nov, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departs from Panama City Tocumen International on Wed, 9 Dec, arriving in San Diego International.Price includes taxes and charges.From $958, select.

Panama City.$988 per passenger.Departing Thu, 3 Dec, returning Thu, 10 Dec.Return flight with Delta.Outbound indirect flight with Delta, departs from San Diego International on Thu, 3 Dec, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departs from Panama City Tocumen International on Thu, 10 Dec, arriving in San Diego International.Price includes taxes and charges.From $988, select.

Panama City.$998 per passenger.Departing Mon, 1 Feb, returning Sat, 6 Feb.Return flight with United.Outbound indirect flight with United, departs from San Diego International on Mon, 1 Feb, arriving in Panama City Tocumen International.Inbound indirect flight with United, departs from Panama City Tocumen International on Sat, 6 Feb, arriving in San Diego International.Price includes taxes and charges.From $998, select.

Panama City.$1,061 per passenger.Departing Tue, 27 Oct, returning Tue, 3 Nov.Return flight with United.Outbound indirect flight with United, departs from San Diego International on Tue, 27 Oct, arriving in Panama City Tocumen International.Inbound indirect flight with United, departs from Panama City Tocumen International on Tue, 3 Nov, arriving in San Diego International.Price includes taxes and charges.From $1,061, select.

Panama City.$1,076 per passenger.Departing Fri, 5 Feb, returning Fri, 12 Feb.Return flight with Copa.Outbound direct flight with Copa departs from San Diego International on Fri, 5 Feb, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Fri, 12 Feb, arriving in San Diego International.Price includes taxes and charges.From $1,076, select.

Panama City.$1,168 per passenger.Departing Mon, 5 Oct, returning Tue, 27 Oct.Return flight with United.Outbound indirect flight with United, departs from San Diego International on Mon, 5 Oct, arriving in Panama City Tocumen International.Inbound indirect flight with United, departs from Panama City Tocumen International on Tue, 27 Oct, arriving in San Diego International.Price includes taxes and charges.From $1,168, select.

Panama City.$1,182 per passenger.Departing Wed, 23 Sep, returning Sun, 27 Sep.Return flight with United.Outbound indirect flight with United, departs from San Diego International on Wed, 23 Sep, arriving in Panama City Tocumen International.Inbound indirect flight with United, departs from Panama City Tocumen International on Sun, 27 Sep, arriving in San Diego International.Price includes taxes and charges.From $1,182, select.

Panama City.$1,207 per passenger.Departing Mon, 26 Oct, returning Mon, 2 Nov.Return flight with Copa.Outbound direct flight with Copa departs from San Diego International on Mon, 26 Oct, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Mon, 2 Nov, arriving in San Diego International.Price includes taxes and charges.From $1,207, select.

Panama City.$1,209 per passenger.Departing Sun, 18 Oct, returning Sun, 25 Oct.Return flight with Copa.Outbound direct flight with Copa departs from San Diego International on Sun, 18 Oct, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Sun, 25 Oct, arriving in San Diego International.Price includes taxes and charges.From $1,209, select.

Panama City.$1,210 per passenger.Departing Wed, 30 Sep, returning Sun, 4 Oct.Return flight with Copa.Outbound direct flight with Copa departs from San Diego International on Wed, 30 Sep, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Sun, 4 Oct, arriving in San Diego International.Price includes taxes and charges.From $1,210, select.

Panama City.$1,271 per passenger.Departing Sun, 17 Jan, returning Sun, 24 Jan.Return flight with United.Outbound indirect flight with United, departs from San Diego International on Sun, 17 Jan, arriving in Panama City Tocumen International.Inbound indirect flight with United, departs from Panama City Tocumen International on Sun, 24 Jan, arriving in San Diego International.Price includes taxes and charges.From $1,271, select.

Panama City.$1,275 per passenger.Departing Sun, 17 Jan, returning Sun, 24 Jan.Return flight with Copa.Outbound direct flight with Copa departs from San Diego International on Sun, 17 Jan, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Sun, 24 Jan, arriving in San Diego International.Price includes taxes and charges.From $1,275, select.

Find the cheapest month to fly from San Diego to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like San Diego to Panama City flights are currently cheapest in April.

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Direct flights from San Diego to Panama City

Alternative San Diego to Panama City routes

Looking for the cheapest, fastest or easiest route from San Diego to Panama City? You could fly into the following airports instead.

San Diego to Panama City: Flight information

The things to know before you go.

Cheapest flight found	$922
Cheapest month to fly	April
Average flight time	6 hrs, 9 mins
Most popular airline	Copa
Average flights per week	9

Finding cheap flights from San Diego to Panama City: Frequently asked questions

How many airports are there in Panama City?

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.

How much are return flights from San Diego to Panama City?

The best price we found for a return flight from San Diego to Panama City is $922. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

How long does it take to fly from San Diego to Panama City?

6 hours and 9 minutes is the average flight time from San Diego to Panama City.

Which airlines fly direct from San Diego to Panama City?

Copa and United fly direct from San Diego to Panama City.

How many flights are there a week from San Diego to Panama City?

As of September 2026, there are 9 flights per week flying from San Diego to Panama City.

When is the cheapest time to fly from San Diego to Panama City?

The cheapest month to fly from San Diego to Panama City is usually April.

Which is the cheapest airport to fly into in Panama City?

If you're flying from San Diego, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the centre of Panama City. We've found flights into this airport from $922.

Which upcoming date is cheapest to fly from San Diego to Panama City on?

After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from San Diego to Panama City on Wednesday, 7 April 2027.

Can I get a direct flight from San Diego to Panama City?

Yes – the average flight time is 6 hours and 9 minutes.

How can I get the best flight deal from San Diego to Panama City?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Panama City?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.

What’s the weather like in Panama City?

In September, the average temperature is usually around 27°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is November, with temperatures averaging 25°C. The rainiest month is July.

Which is the cheapest airline to fly from San Diego to Panama City with?

The cheapest airline that flies to Panama City is Copa .

Travelling from San Diego to Panama City: what you need to know

San Diego International Airport (SAN) is San Diego's main airport. Explore your options for booking a flight from San Diego to Panama City departing from here.
Touch down in Panama City at Panama City Tocumen International Airport (PTY) or Balboa Airport (BLB).
The average duration of a direct San Diego to Panama City flight is 6 hours 10 minutes.
Panama City is three hours ahead of San Diego and observes the UTC-5 timezone.
With four weekly flights between the two airports, San Diego International Airport (SAN) to Panama City Tocumen International Airport (PTY) is the most popular route. Hop on the earliest flight from San Diego to Panama City with Copa Airlines at 20:06. If you'd like to get more out of your day before leaving, the latest flight from SAN to PTY is with Copa Airlines at 21:07.
For a stress-free journey, turn up at the airport two hours ahead of international flights and an hour before domestic departures. This leaves you with plenty of time to board your San Diego to Panama City flight.
Travelling during a peak time like August? Public holidays and other high seasons can mean longer queues and delays at check-in and security. Be extra cautious and get there up to four hours ahead of international flights and two hours before domestic departures.

How to find the cheapest flights from San Diego to Panama City

$414 is the best price for a one-way ticket from San Diego to Panama City. A return flight starts from $922. These fares may change based on demand and availability.
Book one month before flying. Pricing trends suggest that this is the ideal window for finding cheap San Diego to Panama City flights.
The best month for finding cheap plane tickets from San Diego to Panama City is June. Use the 'Whole month' tool to compare all available prices, then select the dates that offer the lowest fares.
You don't need to check back in every day to find out if fares have dropped when you create a Price Alert. We'll tell you as soon as a better deal comes up on cheap flights from San Diego to Panama City.
Tailor your trip using filters. Choose your arrival and departure times, airlines and total journey duration. You can also sort the results by 'Fastest,' 'Best' or 'Cheapest' San Diego to Panama City flights.

Flying from San Diego

San Diego International Airport (SAN)

You can get a direct flight from San Diego to Panama City leaving from San Diego International Airport (SAN). Begin your trip at SAN and land at Panama City Tocumen International Airport (PTY).
Copa Airlines is a leading airline that offers direct San Diego to Panama City plane tickets leaving from SAN.
Consider adding a stopover to potentially save money on your San Diego to Panama City flight. Just uncheck 'Direct flights only' when searching for departures from San Diego International Airport. Break up your trip (and maybe save some cash) by stopping at one of these popular options:
- Houston George Bush Intercntl. Airport (IAH)
- Austin-Bergstrom Airport (AUS)
- Tampa International Airport (TPA)
SAN is about 5 kilometres from central San Diego. If you're catching a taxi, ride-sharing or driving from the centre, it'll take 15 minutes or so to get there, depending on traffic conditions. If you're using public transport, expect the trip time to be around 25 minutes.
Catching an early flight from San Diego to Panama City? Avoid the last-minute rush to the terminal (and get some extra shut-eye) by choosing one of these hotels close to San Diego International Airport:
Of all flights departing from San Diego International Airport, 74% arrive on time at their destination.
SAN is located at N Harbour Dr.

Arriving in Panama City

Panama City Tocumen International Airport (PTY)

The distance from Panama City Tocumen International Airport (PTY) to central Panama City is roughly 18 kilometres. It takes about 35 minutes to reach the centre driving.
When travelling on public transport, expect a journey time of about 50 minutes.
Consider staying in a hotel close to PTY if you're coming in on a late flight from San Diego to Panama City. Settle into one of these accommodation options and avoid the hassle of a long transfer:
Go where the road takes you with a Panama City Tocumen International Airport rental car. Pick up your wheels from Avis, Dollar or MEX and discover more of Panama City and beyond.
Lock in the lowest price by booking your ride from Panama City Tocumen International Airport about three weeks before your departure date.

Panama City Paitilla Airport (PAC)

If you're staying in Panama City's centre (or just want to explore straight away), the city is around 5 kilometres from Panama City Paitilla Airport (PAC). Look for any information desks for help with directions after disembarking your flight from San Diego to Panama City.
Hang up the 'Do not disturb' sign and relax at a hotel near PAC. Here are a few options where you can settle in after your flight from San Diego to Panama City:
The quickest way to get to where you're going is with a Panama City Paitilla Airport rental car. Pick up your wheels from Thrifty, Avis or Alamo and be off and running.
Avoid paying more than you need to. Securing your ride three weeks before your arrival at PAC can land you a better rate.

Balboa Airport (BLB)

Balboa Airport (BLB) is around 5 kilometres from the centre of Panama City. It'll take you about 10 minutes to reach the city centre by ride-share or taxi once you've stepped off your flight from San Diego to Panama City.
If you go by public transport, the journey time is about 20 minutes.
Whether you're after a mini for a solo adventure or an SUV to transport your group, you'll find the ideal Balboa Airport rental car for your needs. Browse the types of wheels available from names such as Sixt, Dollar and Thrifty.
Enjoy a payoff when you plan ahead. Book your vehicle from BLB one week before your flight from San Diego to Panama City for the lowest prices.

Best time to go to Panama City

It's time to work out your travel dates for your flight from San Diego to Panama City. July is the busiest month for a trip to Panama City. If you prefer a more relaxed vibe, go in March.
The warmest month in Panama City is March, with temperatures ranging between 21ºC and 32ºC. Book your San Diego to Panama City ticket then if that's your idea of comfortable weather.
If you like cooler conditions, look for a cheap flight from San Diego to Panama City in January when temperatures average between 22ºC and 31ºC.

More about Panama City

Once you've booked your flight from San Diego to Panama City, find a hotel that keeps you close to what you want to see. Make one of these options your base for exploring Panama City:
There are so many things to discover in this city it can be hard to know where to start. San Felipe, Metropolitan Cathedral Basilica of Santa Maria the Ancient and Independence Square are major attractions which should be on any well-planned Panama City itinerary.