Cheap Flights from St Louis to Panama City

Compare St Louis to Panama City flight deals

Find the cheapest month or even day of the year to fly to Panama City

Book the best Panama City fare with no extra fees

Flight deals from St Louis to Panama City

Looking for a cheap last-minute deal or the best return flight from St Louis Airport to Panama City? If you want to travel next month, return fares start from $1,042. Find the lowest prices on one-way and return tickets right here.

Panama City.$1,042 per passenger.Departing Mon, 28 Sep, returning Mon, 5 Oct.Return flight with Delta.Outbound indirect flight with Delta, departs from St Louis on Mon, 28 Sep, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departs from Panama City Tocumen International on Mon, 5 Oct, arriving in St Louis.Price includes taxes and charges.From $1,042, select.

Panama City.$1,042 per passenger.Departing Mon, 28 Sep, returning Tue, 29 Sep.Return flight with Delta.Outbound indirect flight with Delta, departs from St Louis on Mon, 28 Sep, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departs from Panama City Tocumen International on Tue, 29 Sep, arriving in St Louis.Price includes taxes and charges.From $1,042, select.

Panama City.$1,062 per passenger.Departing Wed, 14 Apr, returning Wed, 21 Apr.Return flight with Delta.Outbound indirect flight with Delta, departs from St Louis on Wed, 14 Apr, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departs from Panama City Tocumen International on Wed, 21 Apr, arriving in St Louis.Price includes taxes and charges.From $1,062, select.

Panama City.$1,070 per passenger.Departing Sat, 27 Mar, returning Thu, 1 Apr.Return flight with United.Outbound indirect flight with United, departs from St Louis on Sat, 27 Mar, arriving in Panama City Tocumen International.Inbound indirect flight with United, departs from Panama City Tocumen International on Thu, 1 Apr, arriving in St Louis.Price includes taxes and charges.From $1,070, select.

Panama City.$1,071 per passenger.Departing Thu, 22 Oct, returning Sun, 1 Nov.Return flight with Delta.Outbound indirect flight with Delta, departs from St Louis on Thu, 22 Oct, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departs from Panama City Tocumen International on Sun, 1 Nov, arriving in St Louis.Price includes taxes and charges.From $1,071, select.

Panama City.$1,071 per passenger.Departing Fri, 2 Oct, returning Wed, 7 Oct.Return flight with United.Outbound indirect flight with United, departs from St Louis on Fri, 2 Oct, arriving in Panama City Tocumen International.Inbound indirect flight with United, departs from Panama City Tocumen International on Wed, 7 Oct, arriving in St Louis.Price includes taxes and charges.From $1,071, select.

Panama City.$1,071 per passenger.Departing Thu, 27 Aug, returning Sat, 5 Sep.Return flight with Delta.Outbound indirect flight with Delta, departs from St Louis on Thu, 27 Aug, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departs from Panama City Tocumen International on Sat, 5 Sep, arriving in St Louis.Price includes taxes and charges.From $1,071, select.

Panama City.$1,100 per passenger.Departing Fri, 28 Aug, returning Fri, 5 Mar.Return flight with United.Outbound indirect flight with United, departs from St Louis on Fri, 28 Aug, arriving in Panama City Tocumen International.Inbound indirect flight with United, departs from Panama City Tocumen International on Fri, 5 Mar, arriving in St Louis.Price includes taxes and charges.From $1,100, select.

Panama City.$1,122 per passenger.Departing Mon, 30 Nov, returning Tue, 15 Dec.Return flight with Delta.Outbound indirect flight with Delta, departs from St Louis on Mon, 30 Nov, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departs from Panama City Tocumen International on Tue, 15 Dec, arriving in St Louis.Price includes taxes and charges.From $1,122, select.

Panama City.$1,135 per passenger.Departing Sat, 21 Nov, returning Tue, 24 Nov.Return flight with United.Outbound indirect flight with United, departs from St Louis on Sat, 21 Nov, arriving in Panama City Tocumen International.Inbound indirect flight with United, departs from Panama City Tocumen International on Tue, 24 Nov, arriving in St Louis.Price includes taxes and charges.From $1,135, select.

Panama City.$1,192 per passenger.Departing Tue, 25 Aug, returning Sat, 29 Aug.Return flight with Delta.Outbound indirect flight with Delta, departs from St Louis on Tue, 25 Aug, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departs from Panama City Tocumen International on Sat, 29 Aug, arriving in St Louis.Price includes taxes and charges.From $1,192, select.

Panama City.$1,464 per passenger.Departing Fri, 5 Feb, returning Sat, 6 Feb.Return flight with Delta.Outbound indirect flight with Delta, departs from St Louis on Fri, 5 Feb, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departs from Panama City Tocumen International on Sat, 6 Feb, arriving in St Louis.Price includes taxes and charges.From $1,464, select.

Panama City.$1,787 per passenger.Departing Sun, 13 Dec, returning Sun, 27 Dec.Return flight with Delta.Outbound indirect flight with Delta, departs from St Louis on Sun, 13 Dec, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departs from Panama City Tocumen International on Sun, 27 Dec, arriving in St Louis.Price includes taxes and charges.From $1,787, select.

Panama City.$1,821 per passenger.Departing Mon, 21 Dec, returning Tue, 12 Jan.Return flight with Delta.Outbound indirect flight with Delta, departs from St Louis on Mon, 21 Dec, arriving in Panama City Tocumen International.Inbound indirect flight with Delta, departs from Panama City Tocumen International on Tue, 12 Jan, arriving in St Louis.Price includes taxes and charges.From $1,821, select.

Panama City.$2,140 per passenger.Departing Fri, 5 Mar, returning Fri, 5 Mar.Return flight with United and Copa.Outbound indirect flight with United, departs from St Louis on Fri, 5 Mar, arriving in Panama City Tocumen International.Inbound indirect flight with Copa, departs from Panama City Tocumen International on Fri, 5 Mar, arriving in St Louis.Price includes taxes and charges.From $2,140, select.

Panama City.$2,298 per passenger.Departing Wed, 13 Jan, returning Fri, 22 Jan.Return flight with United.Outbound indirect flight with United, departs from St Louis on Wed, 13 Jan, arriving in Panama City Tocumen International.Inbound indirect flight with United, departs from Panama City Tocumen International on Fri, 22 Jan, arriving in St Louis.Price includes taxes and charges.From $2,298, select.

Find the cheapest month to fly from St Louis to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like St Louis to Panama City flights are currently cheapest in September.

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Alternative St Louis to Panama City routes

Looking for the cheapest, fastest or easiest route from St Louis to Panama City? You could fly into the following airports instead.

St Louis to Panama City: Flight information

The things to know before you go.

Cheapest flight found	$1,042
Cheapest month to fly	September

Finding cheap flights from St Louis to Panama City: Frequently asked questions

How many airports are there in Panama City?

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.

How much are return flights from St Louis to Panama City?

The best price we found for a return flight from St Louis to Panama City is $1,042. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

Which airlines fly direct from St Louis to Panama City?

Currently, there are no airlines that fly direct from St Louis to Panama City. But we found flights with one or more stops from $1,042.

How many flights are there a week from St Louis to Panama City?

As of August 2026, there are no flights flying from St Louis to Panama City.

When is the cheapest time to fly from St Louis to Panama City?

The cheapest month to fly from St Louis to Panama City is usually September.

Which is the cheapest airport to fly into in Panama City?

If you're flying from St Louis Airport, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the centre of Panama City. We've found flights into this airport from $1,042.

Which upcoming date is cheapest to fly from St Louis Airport to Panama City on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from St Louis Airport to Panama City on Monday, 28 September 2026.

Can I get a direct flight from St Louis Airport to Panama City?

No airlines currently offer direct flights between St Louis Airport and Panama City. Most routes have one or more stops.

How can I get the best flight deal from St Louis Airport to Panama City?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Panama City?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.

What’s the weather like in Panama City?

In August, the average temperature is usually around 27°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.

Which is the cheapest airline to fly from St Louis Airport to Panama City with?

Currently, Delta offers the cheapest flight tickets to Panama City.

Flying from St Louis Lambert International Airport (STL) to Panama City: what you need to know

Panama City is one hour ahead of St Louis, where St Louis Lambert International Airport is located. Panama City observes the UTC-5 timezone.
To avoid rushing for your STL to Panama City flight, leave plenty of time for things like check-in and baggage drop. Arriving two hours ahead of international departures and an hour before domestic flights is the general rule.
During popular months such as July, you'll want to get to the airport even earlier. Arrive two hours before a domestic departure and four hours ahead for international flights when you fly during high season in general.
Consider adding a stopover to potentially unlock a cheaper plane ticket from STL to Panama City. All you need to do is deselect 'Direct flights only' during your search. Take a break (and maybe save some cash) by stopping at one of these connecting airports:
- Atlanta Hartsfield-Jackson International Airport (ATL)
- Orlando International Airport (MCO)
- Cancun International Airport (CUN)
Located around 16 kilometres from central St Louis, STL can be reached in about 25 minutes by car. Travelling on public transport will take roughly 30 minutes.
Want a leisurely start to your trip? Stay near STL. Whether you're catching an early flight from St Louis Lambert International Airport to Panama City or just don't like being rushed, these hotels have you covered:
When it comes to St Louis Lambert International Airport's on-time performance, data shows 76% of flights complete their journey on time.
You'll find STL at 10701 Lambert International Blvd..

How to find the cheapest flights from St Louis Lambert International Airport (STL) to Panama City

The best price we've found for a one-way St Louis Lambert International Airport to Panama City flight is $467. The cheapest price for a return flight is $1,042. Remember fares may change due to availability at the time of booking.
Don't wait until the last moment. You're more likely to land cheap flights from STL to Panama City if you book in advance. Airlines often offer some excellent early bird discounts.
The 'Whole month' tool will show you the cheapest tickets from St Louis Lambert International Airport to Panama City across every month. It's a good way to snap up a bargain if your plans are flexible.
Locking in a cheap flight from STL to Panama City is a breeze with Price Alerts. Simply create one of these automatic notifications and we'll notify you when a new discount appears.
Tailor your flights with filters. Select your preferred arrival and departure times, airlines and total journey duration. You can also sort your results by 'Best,' 'Cheapest' or 'Fastest' flights from St Louis Lambert International Airport to Panama City.

Airports in Panama City

Panama City Tocumen International Airport (PTY)

The distance from Panama City Tocumen International Airport (PTY) to central Panama City is roughly 24 kilometres. It takes around 35 minutes to reach the centre driving.
Travelling on public transport will take you around 50 minutes.
If you have a late flight from St Louis Lambert International Airport to Panama City, few things beat the convenience of staying close to the terminal. Collect your bags from the carousel and then be showered and sleeping not long after at one of these accommodation options near PTY:
For the lowest price, reserve your vehicle from Panama City Tocumen International Airport around three weeks ahead of your flight from STL to Panama City.

Panama Pacifico International Airport (BLB)

Once your flight from St Louis Lambert International Airport to Panama City has landed, you can get to the city centre in about 10 minutes by car. Central Panama City is roughly 6 kilometres from Panama Pacifico International Airport (BLB).
If you choose to travel on public transport, you'll get to the city centre in 20 minutes or so.
Following your STL to Panama City flight, tuck yourself in at a hotel near BLB. These are some great options that'll help you get into relaxation mode:
Avoid last-minute price surges. Reserving your ride one week ahead of your arrival at BLB will help you save.

Best time to go to Panama City

January is the most popular month for flights from St Louis Lambert International Airport to Panama City. To avoid the crowds, visit Panama City in September.
The warmest month in Panama City is March, with temperatures ranging between 21ºC and 32ºC. Lock in your St Louis Lambert International Airport to Panama City plane ticket then if this is the type of weather you enjoy.
Look for cheap tickets from STL to Panama City in January if you like travelling in cooler conditions. Temperatures are at their lowest then, ranging between 22ºC and 31ºC on average.

More about Panama City

When it comes to searching for somewhere to lay your head, you'll find the best stays in Panama City right here. Check out these hotels once you've locked in your flight from St Louis Lambert International Airport to Panama City:
There are so many things to discover in this city it can be difficult to know where to start. Metropolitan Cathedral (Catedral Metropolitan), Casco Viejo and Independence Square are leading attractions which should be on every Panama City itinerary.

Explore more of Panama

David is just one of the many cities in Panama waiting to be discovered after you've seen Panama City. Around 322 kilometres away to the west, popular attractions include Museo Antropológico y Etnográfico Dr. Roberto De La Guardia, Raptors To The Rescue and Unachi Botanical garden.
Your trip through Panama wouldn't be as memorable without a stop in Santiago de Veraguas. Santiago the Apostle Cathedral, Santiago de Veraguas is just one of the highlights in this destination, which is around 193 kilometres southwest of Panama City.