Cheap Flights from St Louis to Knoxville

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Compare St Louis to Knoxville flight deals

Find the cheapest month or even day of the year to fly to Knoxville

Book the best Knoxville fare with no extra fees

Flight deals Cheapest month Find the best route Route info FAQs Tips and advice

Flight deals from St Louis to Knoxville

Looking for a cheap last-minute deal or the best return flight from St Louis Airport to Knoxville Airport? If you want to travel next month, return fares start from $484. Find the lowest prices on one-way and return tickets right here.

Knoxville.$432 per passenger.Departing Wed, 7 Oct, returning Wed, 14 Oct.Return flight with Delta.Outbound indirect flight with Delta, departs from St Louis on Wed, 7 Oct, arriving in Knoxville.Inbound indirect flight with Delta, departs from Knoxville on Wed, 14 Oct, arriving in St Louis.Price includes taxes and charges.From $432, select.

Knoxville.$478 per passenger.Departing Mon, 1 Mar, returning Thu, 4 Mar.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from St Louis on Mon, 1 Mar, arriving in Knoxville.Inbound indirect flight with Southwest Airlines, departs from Knoxville on Thu, 4 Mar, arriving in St Louis.Price includes taxes and charges.From $478, select.

Knoxville.$484 per passenger.Departing Mon, 21 Sep, returning Thu, 24 Sep.Return flight with United.Outbound indirect flight with United, departs from St Louis on Mon, 21 Sep, arriving in Knoxville.Inbound indirect flight with United, departs from Knoxville on Thu, 24 Sep, arriving in St Louis.Price includes taxes and charges.From $484, select.

Knoxville.$484 per passenger.Departing Wed, 11 Nov, returning Sun, 15 Nov.Return flight with Delta.Outbound indirect flight with Delta, departs from St Louis on Wed, 11 Nov, arriving in Knoxville.Inbound indirect flight with Delta, departs from Knoxville on Sun, 15 Nov, arriving in St Louis.Price includes taxes and charges.From $484, select.

Knoxville.$512 per passenger.Departing Fri, 30 Oct, returning Sun, 1 Nov.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from St Louis on Fri, 30 Oct, arriving in Knoxville.Inbound indirect flight with Southwest Airlines, departs from Knoxville on Sun, 1 Nov, arriving in St Louis.Price includes taxes and charges.From $512, select.

Knoxville.$522 per passenger.Departing Sun, 9 May, returning Sat, 15 May.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from St Louis on Sun, 9 May, arriving in Knoxville.Inbound indirect flight with Southwest Airlines, departs from Knoxville on Sat, 15 May, arriving in St Louis.Price includes taxes and charges.From $522, select.

Knoxville.$616 per passenger.Departing Thu, 24 Sep, returning Thu, 1 Oct.Return flight with Delta.Outbound indirect flight with Delta, departs from St Louis on Thu, 24 Sep, arriving in Knoxville.Inbound indirect flight with Delta, departs from Knoxville on Thu, 1 Oct, arriving in St Louis.Price includes taxes and charges.From $616, select.

Knoxville.$773 per passenger.Departing Mon, 28 Dec, returning Mon, 28 Dec.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from St Louis on Mon, 28 Dec, arriving in Knoxville.Inbound indirect flight with Southwest Airlines, departs from Knoxville on Mon, 28 Dec, arriving in St Louis.Price includes taxes and charges.From $773, select.

Knoxville.$800 per passenger.Departing Mon, 28 Dec, returning Sun, 3 Jan.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from St Louis on Mon, 28 Dec, arriving in Knoxville.Inbound indirect flight with Southwest Airlines, departs from Knoxville on Sun, 3 Jan, arriving in St Louis.Price includes taxes and charges.From $800, select.

Find the cheapest month to fly from St Louis to Knoxville

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like St Louis to Knoxville flights are currently cheapest in October.

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St Louis to Knoxville: Alternative routes

Compare routes from St Louis to Knoxville below. You may find an airport to fly into that's cheaper, faster, or easier than Knoxville.

Knoxville

18km from central Knoxville

ClosestCheapest

from $432

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St Louis to Knoxville: Flight information

The things to know before you go.

Cheapest flight found	$432
Cheapest month to fly	October

Finding cheap flights from St Louis to Knoxville: Frequently asked questions

How much are return flights from St Louis to Knoxville?

The best price we found for a return flight from St Louis to Knoxville is $432. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

Which airlines fly direct from St Louis to Knoxville?

Currently, there are no airlines that fly direct from St Louis to Knoxville. But we found flights with one or more stops from $432.

How many flights are there a week from St Louis to Knoxville?

As of August 2026, there are no flights flying from St Louis to Knoxville.

When is the cheapest time to fly from St Louis to Knoxville?

The cheapest month to fly from St Louis to Knoxville is usually October.

Which upcoming date is cheapest to fly from St Louis Airport to Knoxville Airport on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from St Louis Airport to Knoxville Airport on Wednesday, 7 October 2026.

Can I get a direct flight from St Louis Airport to Knoxville Airport?

No airlines currently offer direct flights between St Louis Airport and Knoxville Airport. Most routes have one or more stops.

How can I find the best flight deal to Knoxville?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Knoxville but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Knoxville?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Knoxville is around 40 days in advance, so don’t leave your flight to the last minute.

Which is the cheapest airline to fly from St Louis Airport to Knoxville with?

Currently, Delta offers the cheapest flight tickets to Knoxville.

Travelling from St Louis Airport (STL) to Knoxville Airport (TYS): what you need to know

Leave enough time to catch your STL to TYS flight. A good rule of thumb is to arrive two hours before international departures and an hour ahead for domestic flights.
Flying during a peak month such as July? School holidays and other high seasons can result in longer lines and delays at check-in and security. Play it safe and get there up to four hours ahead of international flights and two hours before a domestic departure.
If you want to break up your flight, just uncheck 'Direct flights only' when searching for your ticket from St Louis Airport to Knoxville Airport. These are the top stopovers between STL and TYS:
- Atlanta Hartsfield-Jackson Airport
- Detroit Wayne County Airport
- Chicago Midway Airport

How to find the cheapest flights from St Louis Airport (STL) to Knoxville Airport (TYS)

The lowest price we've seen for a one-way St Louis Airport to Knoxville Airport flight is $203. A return ticket right now is $432. Depending on the availability and when you book, these fares may change.
To find cheap tickets from STL to TYS, book early. Airlines typically offer their best fares when flights are first made available.
Finding cheap flights from St Louis Airport to Knoxville Airport is easier if you can be flexible with your travel plans. Use the 'Whole month' tool to see the lowest fares across each month and bag a great deal.
There's no need to check every day to see if fares have dropped when you create a Price Alert. We'll send you an update the moment a special offer becomes available on cheap flights from STL to TYS.
Find the right flight for you with the help of the filters. To see the 'Cheapest,' 'Best' or 'Fastest' flights from St Louis Airport to Knoxville Airport, use the 'Sort by' function. You can also filter by airline, departure and arrival times, and journey duration.

Handy information about St Louis Airport (STL)

STL's address is 10701 Lambert International Blvd..
Of the departures from St Louis Airport, 76% arrive on time at their destination.
St Louis Airport is about 24 kilometres from central St Louis. If you're ride-sharing, catching a taxi or driving from the centre, it'll take you 25 minutes or so to get there, depending on the traffic.
The journey on public transport takes roughly 30 minutes.
Get your holiday off to a leisurely start by staying near STL. Whether you've booked an early flight from St Louis Airport to Knoxville Airport or just don't like being rushed, these hotels are perfect:

Arriving at Knoxville Airport (TYS)

If you're getting in on a late St Louis Airport to Knoxville Airport flight, nothing tops the convenience of staying near the terminal. Grab your luggage from the carousel and then be showered and resting not long after at one of these hotels near TYS:
Pick up a Knoxville Airport rental car and discover Knoxville and beyond with your own set of wheels. Budget, Alamo and Avis are well-known companies you can book with here.
Reserving your ride from Knoxville Airport about three weeks in advance boosts your odds of scoring a great price.

When to fly to Knoxville Airport (TYS)

The quietest month for a flight from St Louis Airport to Knoxville Airport is March, while October is the most popular. Choose the best time to visit Knoxville based on whether you prefer a more relaxed vibe or a faster pace.
Book your flight from St Louis Airport to Knoxville Airport for July if you'd like to explore Knoxville during its warmest month. Expect temperatures of between 17ºC and 32ºC.
January has average temperatures of between -6ºC and 11ºC. Search for cheap tickets from STL to TYS sometime then if you want to travel in cooler conditions.

Explore more of the United States

Columbus is just one of the many cities in the United States waiting to be explored once you've seen Knoxville. Around 451 kilometres away to the north, well-known attractions include Franklin Park Conservatory and Botanical Gardens, Whetstone Park / Park of Roses and Ohio Theatre.
Around 467 kilometres north-west of Knoxville, Indianapolis is another favourite stop in the United States. Start your sightseeing at Lucas Oil Stadium, Eiteljorg Museum and The Children's Museum of Indianapolis.