Cheap Flights from Buffalo Niagara to Knoxville

Compare Buffalo Niagara to Knoxville flight deals

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Flight deals from Buffalo Niagara to Knoxville

Looking for a cheap last-minute deal or the best return flight from Buffalo Niagara Airport to Knoxville Airport? If you want to travel next month, return fares start from $593. Find the lowest prices on one-way and return tickets right here.

Knoxville.$558 per passenger.Departing Sat, 3 Oct, returning Sat, 10 Oct.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from Buffalo Niagara on Sat, 3 Oct, arriving in Knoxville.Inbound indirect flight with Southwest Airlines, departs from Knoxville on Sat, 10 Oct, arriving in Buffalo Niagara.Price includes taxes and charges.From $558, select.

Knoxville.$593 per passenger.Departing Fri, 7 Aug, returning Mon, 10 Aug.Return flight with Delta.Outbound indirect flight with Delta, departs from Buffalo Niagara on Fri, 7 Aug, arriving in Knoxville.Inbound indirect flight with Delta, departs from Knoxville on Mon, 10 Aug, arriving in Buffalo Niagara.Price includes taxes and charges.From $593, select.

Knoxville.$626 per passenger.Departing Fri, 6 Nov, returning Sun, 8 Nov.Return flight with Delta.Outbound indirect flight with Delta, departs from Buffalo Niagara on Fri, 6 Nov, arriving in Knoxville.Inbound indirect flight with Delta, departs from Knoxville on Sun, 8 Nov, arriving in Buffalo Niagara.Price includes taxes and charges.From $626, select.

Knoxville.$627 per passenger.Departing Mon, 14 Sep, returning Sun, 20 Sep.Return flight with Delta.Outbound indirect flight with Delta, departs from Buffalo Niagara on Mon, 14 Sep, arriving in Knoxville.Inbound indirect flight with Delta, departs from Knoxville on Sun, 20 Sep, arriving in Buffalo Niagara.Price includes taxes and charges.From $627, select.

Knoxville.$699 per passenger.Departing Thu, 30 Jul, returning Wed, 5 Aug.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from Buffalo Niagara on Thu, 30 Jul, arriving in Knoxville.Inbound indirect flight with Southwest Airlines, departs from Knoxville on Wed, 5 Aug, arriving in Buffalo Niagara.Price includes taxes and charges.From $699, select.

Knoxville.$769 per passenger.Departing Thu, 16 Jul, returning Sun, 19 Jul.Return flight with United.Outbound indirect flight with United, departs from Buffalo Niagara on Thu, 16 Jul, arriving in Knoxville.Inbound indirect flight with United, departs from Knoxville on Sun, 19 Jul, arriving in Buffalo Niagara.Price includes taxes and charges.From $769, select.

Find the cheapest month to fly from Buffalo Niagara to Knoxville

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Buffalo Niagara to Knoxville flights are currently cheapest in October.

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Buffalo Niagara to Knoxville: Alternative routes

Compare routes from Buffalo Niagara to Knoxville below. You may find an airport to fly into that's cheaper, faster, or easier than Knoxville.

Knoxville

18km from central Knoxville

ClosestCheapest

from $558

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Buffalo to Knoxville: Flight information

The things to know before you go.

Cheapest flight found	$558
Cheapest month to fly	October

Finding cheap flights from Buffalo Niagara to Knoxville: Frequently asked questions

How much are return flights from Buffalo Niagara to Knoxville?

The best price we found for a return flight from Buffalo Niagara to Knoxville is $558. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

Which airlines fly direct from Buffalo Niagara to Knoxville?

Currently, there are no airlines that fly direct from Buffalo Niagara to Knoxville. But we found flights with one or more stops from $558.

How many flights are there a week from Buffalo Niagara to Knoxville?

As of July 2026, there are no flights flying from Buffalo Niagara to Knoxville.

When is the cheapest time to fly from Buffalo Niagara to Knoxville?

The cheapest month to fly from Buffalo Niagara to Knoxville is usually October.

Which upcoming date is cheapest to fly from Buffalo Niagara Airport to Knoxville Airport on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Buffalo Niagara Airport to Knoxville Airport on Saturday, 3 October 2026.

Can I get a direct flight from Buffalo Niagara Airport to Knoxville Airport?

No airlines currently offer direct flights between Buffalo Niagara Airport and Knoxville Airport. Most routes have one or more stops.

How can I find the best flight deal to Knoxville?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Knoxville but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Knoxville?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Knoxville is around 40 days in advance, so don’t leave your flight to the last minute.

Which is the cheapest airline to fly from Buffalo Niagara Airport to Knoxville with?

Currently, Southwest Airlines offers the cheapest flight tickets to Knoxville.

Travelling from Buffalo Niagara Airport (BUF) to Knoxville Airport (TYS): what you need to know

Arriving two hours before an international flight and one hour ahead of a domestic departure are tried-and-true travel tips. Be at the airport on time to board your BUF to TYS flight.
Flying during a peak time like August? Major public holidays and other high seasons can lead to longer lines and delays at airport checkpoints. Be extra cautious and arrive up to four hours before an international flight and two hours before domestic departures.
We make it a breeze to book a flight with a stopover. To see your options for tickets from Buffalo Niagara Airport to Knoxville Airport, uncheck 'Direct flights only.' Then, choose a flight that has a stop long enough to tour your chosen city. Some great stopovers between BUF and TYS include:
- Atlanta Hartsfield-Jackson Airport
- Charlotte Douglas Airport
- Detroit Wayne County Airport

How to find the cheapest flights from Buffalo Niagara Airport (BUF) to Knoxville Airport (TYS)

$246 is the best price for a one-way Buffalo Niagara Airport to Knoxville Airport flight. A return flight starts from $558. These fares may change depending on availability.
Don't leave things to the last moment. You're more likely to get cheap tickets from BUF to TYS if you book in advance. Airlines often have some great early bird deals.
If you can be flexible with your travel dates, use the 'Whole month' search tool. It'll find the cheapest price across the month when looking for a flight from Buffalo Niagara Airport to Knoxville Airport.
You don't need to check back in every day to see if fares have dropped when you create a Price Alert. We'll send you an update the moment there's a better deal on cheap flights from BUF to TYS.
Pick your ideal arrival and departure times, number of stops and airlines with the filters. Or sort your results by 'Cheapest' to get the best deals on flights from Buffalo Niagara Airport to Knoxville Airport.

Handy information about Buffalo Niagara Airport (BUF)

You'll find BUF at Genesee Street.
When it comes to Buffalo Niagara Airport's on-time performance, 74% of flights stick to their scheduled arrival time.
Buffalo Niagara Airport is around 16 kilometres from central Buffalo. If you're driving, catching a taxi or ride-sharing from the centre, it'll take you 20 minutes or so to arrive, depending on the traffic.
Catching public transport? Expect a trip time of around 40 minutes.
Have an early flight from Buffalo Niagara Airport to Knoxville Airport? Avoid the hassle of rushing to the airport (and sneak in some extra snooze time) by picking one of these hotels close to BUF:

Arriving at Knoxville Airport (TYS)

If you're getting in on a late Buffalo Niagara Airport to Knoxville Airport flight, nothing tops the convenience of staying near the terminal. Collect your bags from the carousel and then be tucked up in bed soon after at one of these options near TYS:
Pick up a Knoxville Airport rental car and explore Knoxville and beyond with your own wheels. Budget, Alamo and Avis are popular providers you can book with here.
Reserving your vehicle from Knoxville Airport around three weeks in advance can help you secure the lowest rate.

Getting from Knoxville Airport (TYS) to central Knoxville

TYS is located at 2055 Alcoa Highway.
Knoxville Airport is roughly 24 kilometres from central Knoxville. Driving there takes about 25 minutes.
It'll take around 50 minutes if you're travelling by public transport.

When to fly to Knoxville Airport (TYS)

It's time to choose your trip dates for your flight from Buffalo Niagara Airport to Knoxville Airport. October is the most popular month to visit Knoxville. If you like a quieter vibe, go in March.
Before locking in your flight from Buffalo Niagara Airport to Knoxville Airport, think about the kind of weather you enjoy. July is the warmest month in Knoxville, with temperatures ranging from 17ºC to 32ºC.
January has average temperatures of between -6ºC and 11ºC. Look for cheap tickets from BUF to TYS sometime around then if you like cooler conditions.

Explore more of the United States

Knoxville has loads to offer, but there are so many other parts of the United States you should also see. About 451 kilometres north of Knoxville, a trip to Columbus will keep you on the move. Start with leading sights like Franklin Park Conservatory and Botanical Gardens, Whetstone Park / Park of Roses and Ohio Theatre.
Indianapolis is another essential stop in the United States and is around 467 kilometres north-west of Knoxville. No journey is complete without visiting Lucas Oil Stadium, Eiteljorg Museum and The Children's Museum of Indianapolis.