Cheap Flights from Charleston to Des Moines

Compare Charleston to Des Moines flight deals

Find the cheapest month or even day of the year to fly to Des Moines

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Flight deals from Charleston to Des Moines

Looking for a cheap last-minute deal or the best return flight from Charleston Airport to Des Moines Airport? If you want to travel next month, return fares start from $555. Find the lowest prices on one-way and return tickets right here.

Des Moines.$555 per passenger.Departing Wed, 22 Jul, returning Tue, 28 Jul.Return flight with Delta.Outbound indirect flight with Delta, departs from Charleston on Wed, 22 Jul, arriving in Des Moines.Inbound indirect flight with Delta, departs from Des Moines on Tue, 28 Jul, arriving in Charleston.Price includes taxes and charges.From $555, select.

Des Moines.$642 per passenger.Departing Sun, 26 Jul, returning Sat, 1 Aug.Return flight with United.Outbound indirect flight with United, departs from Charleston on Sun, 26 Jul, arriving in Des Moines.Inbound indirect flight with United, departs from Des Moines on Sat, 1 Aug, arriving in Charleston.Price includes taxes and charges.From $642, select.

Find the cheapest month to fly from Charleston to Des Moines

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Charleston to Des Moines flights are currently cheapest in July.

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Charleston to Des Moines: Alternative routes

Compare routes from Charleston to Des Moines below. You may find an airport to fly into that's cheaper, faster, or easier than Des Moines.

Des Moines

8km from central Des Moines

ClosestCheapest

from $554

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Charleston to Des Moines: Flight information

The things to know before you go.

Cheapest flight found	$554
Cheapest month to fly	July

Finding cheap flights from Charleston to Des Moines: Frequently asked questions

How much are return flights from Charleston to Des Moines?

The best price we found for a return flight from Charleston to Des Moines is $555. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

Which airlines fly direct from Charleston to Des Moines?

Currently, there are no airlines that fly direct from Charleston to Des Moines. But we found flights with one or more stops from $554.

How many flights are there a week from Charleston to Des Moines?

As of June 2026, there are no flights flying from Charleston to Des Moines.

When is the cheapest time to fly from Charleston to Des Moines?

The cheapest month to fly from Charleston to Des Moines is usually July.

Which upcoming date is cheapest to fly from Charleston Airport to Des Moines Airport on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Charleston Airport to Des Moines Airport on Wednesday, 22 July 2026.

Can I get a direct flight from Charleston Airport to Des Moines Airport?

No airlines currently offer direct flights between Charleston Airport and Des Moines Airport. Most routes have one or more stops.

How can I find the best flight deal to Des Moines?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Des Moines but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Des Moines?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Des Moines is around 40 days in advance, so don’t leave your flight to the last minute.

Which is the cheapest airline to fly from Charleston Airport to Des Moines with?

Currently, Delta offers the cheapest flight tickets to Des Moines.

Flying from Charleston Airport (CHS) to Des Moines Airport (DSM): what you need to know

Get to the airport on time so you don't miss your CHS to DSM flight. Be there at least two hours ahead for international flights and an hour early for domestic departures to avoid any last-minute rush.
Be prepared for bigger queues in popular months like July. Arriving up to four hours ahead of an international flight and two hours for domestic departures is a wise move.
Consider adding a stopover when booking your ticket from Charleston Airport to Des Moines Airport. Simply deselect 'Direct flights only' to break up your trip, or perhaps explore a new destination along the way. Here's where you can stop between CHS and DSM:
- Chicago O'Hare International Airport
- Charlotte Douglas Airport
- Detroit Wayne County Airport

How to find the cheapest flights from Charleston Airport (CHS) to Des Moines Airport (DSM)

The lowest price we've seen for a one-way Charleston Airport to Des Moines Airport flight is $275. A return plane ticket right now is $555. Depending on the availability when you book, these fares could change.
It's often best to book ahead of time if you want to find cheap tickets from CHS to DSM. That's because flight prices are based on demand, which tends to increase closer to departure.
Finding cheap flights from Charleston Airport to Des Moines Airport is easier if you can be flexible with your travel dates. Use the 'Whole month' search function to see the lowest fares across every month and score a great deal.
Cut down on the time spent looking for cheap flights from CHS to DSM by creating a Price Alert. You'll get an email or push notification on the app when a new low fare is offered.
Select your preferred departure and arrival times, number of stops and airlines with the filters. Alternatively, sort your results by 'Cheapest' to get the best deals on flights from Charleston Airport to Des Moines Airport.

Handy information about Charleston Airport (CHS)

When it comes to Charleston Airport's on-time performance, data shows 79% of flights stick to their scheduled arrival time.
To get to Charleston Airport from central Charleston, it takes around 25 minutes if you're travelling by car. This depends on traffic though. It's approximately 19 kilometres from the airport to the city centre.
The trip when using public transport usually takes 50 minutes.
Looking for a convenient hotel near CHS? If you're catching an early flight from Charleston Airport to Des Moines Airport, these accommodation options will have you sleeping moments from your check-in counter:

Arriving at Des Moines Airport (DSM)

Book a hotel near DSM if you have a late Charleston Airport to Des Moines Airport flight. Check in to one of these options and skip the long transfer after landing:
Go wherever you want, whenever you want with a Des Moines Airport rental car. Pick up a set of wheels from Hertz, Enterprise or Alamo and chase adventure across Des Moines and beyond.
Reserve your vehicle from Des Moines Airport several weeks before your departure date to get the lowest price. If you're going away during peak season, it's a good idea to book even earlier.

Getting from Des Moines Airport (DSM) to central Des Moines

DSM is located at 5800 Fleur Drive, Suite 201.
Des Moines Airport is roughly 11 kilometres from central Des Moines. Driving there takes about 15 minutes.
It takes roughly 30 minutes when travelling by public transport.

When to fly to Des Moines Airport (DSM)

It's time to pick your travel dates for your flight from Charleston Airport to Des Moines Airport. August is the most popular month to head to Des Moines. If you prefer a quieter vibe, go in March.
When reserving your flight from Charleston Airport to Des Moines Airport, consider the type of weather you enjoy. July is the warmest month in Des Moines, with the temperature ranging from 15ºC to 31ºC.
January sees average temperatures of between -13ºC and 2ºC. Search for cheap tickets from CHS to DSM sometime around then if you'd rather travel in cooler conditions.

Explore more of the United States

Chicago is just one of the many cities in the United States waiting to be discovered after you've seen Des Moines. Around 499 kilometres away to the east, well-known attractions include Millennium Park, Art Institute of Chicago and Willis Tower.
Around 499 kilometres east of Des Moines, Milwaukee is another favourite stop in the United States. No visit is complete without checking out Richards Duplex Apartments by Frank Lloyd Wright, Miller Park and Milwaukee County Zoo.