Cheap Flights from Des Moines to Florence

Compare Des Moines to Florence flight deals

Find the cheapest month or even day of the year to fly to Florence

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Flight deals from Des Moines to Florence

Looking for a cheap last-minute deal or the best return flight from Des Moines Airport to Florence Airport? If you want to travel next month, return fares start from $4,630. Find the lowest prices on one-way and return tickets right here.

Florence.$1,550 per passenger.Departing Wed, 14 Apr, returning Wed, 21 Apr.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Wed, 14 Apr, arriving in Florence.Inbound indirect flight with Delta, departs from Florence on Wed, 21 Apr, arriving in Des Moines.Price includes taxes and charges.From $1,550, select.

Florence.$1,693 per passenger.Departing Thu, 30 Jul, returning Thu, 6 Aug.Return flight with Lufthansa.Outbound indirect flight with Lufthansa, departs from Des Moines on Thu, 30 Jul, arriving in Florence.Inbound indirect flight with Lufthansa, departs from Florence on Thu, 6 Aug, arriving in Des Moines.Price includes taxes and charges.From $1,693, select.

Florence.$1,970 per passenger.Departing Sat, 12 Sep, returning Sat, 19 Sep.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Sat, 12 Sep, arriving in Florence.Inbound indirect flight with Delta, departs from Florence on Sat, 19 Sep, arriving in Des Moines.Price includes taxes and charges.From $1,970, select.

Florence.$2,140 per passenger.Departing Mon, 3 Aug, returning Mon, 10 Aug.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Mon, 3 Aug, arriving in Florence.Inbound indirect flight with Delta, departs from Florence on Mon, 10 Aug, arriving in Des Moines.Price includes taxes and charges.From $2,140, select.

Florence.$2,399 per passenger.Departing Mon, 23 Nov, returning Mon, 30 Nov.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Mon, 23 Nov, arriving in Florence.Inbound indirect flight with Delta, departs from Florence on Mon, 30 Nov, arriving in Des Moines.Price includes taxes and charges.From $2,399, select.

Florence.$4,630 per passenger.Departing Sat, 11 Jul, returning Fri, 17 Jul.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Sat, 11 Jul, arriving in Florence.Inbound indirect flight with Delta, departs from Florence on Fri, 17 Jul, arriving in Des Moines.Price includes taxes and charges.From $4,630, select.

Find the cheapest month to fly from Des Moines to Florence

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Des Moines to Florence flights are currently cheapest in April.

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Des Moines to Florence: Alternative routes

Compare routes from Des Moines to Florence below. You may find an airport to fly into that's cheaper, faster, or easier than Florence.

Des Moines to Florence: Flight information

The things to know before you go.

Cheapest flight found	$1,550
Cheapest month to fly	April

Finding cheap flights from Des Moines to Florence: Frequently asked questions

How much are return flights from Des Moines to Florence?

The best price we found for a return flight from Des Moines to Florence is $1,550. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

Which airlines fly direct from Des Moines to Florence?

Currently, there are no airlines that fly direct from Des Moines to Florence. But we found flights with one or more stops from $1,550.

How many flights are there a week from Des Moines to Florence?

As of June 2026, there are no flights flying from Des Moines to Florence.

When is the cheapest time to fly from Des Moines to Florence?

The cheapest month to fly from Des Moines to Florence is usually April.

Which upcoming date is cheapest to fly from Des Moines Airport to Florence Airport on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to Florence Airport on Wednesday, 14 April 2027.

Can I get a direct flight from Des Moines Airport to Florence Airport?

No airlines currently offer direct flights between Des Moines Airport and Florence Airport. Most routes have one or more stops.

How can I find the best flight deal to Florence?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Florence but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Florence?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Florence is around 40 days in advance, so don’t leave your flight to the last minute.

Which is the cheapest airline to fly from Des Moines Airport to Florence with?

Currently, Delta offers the cheapest flight tickets to Florence.

Travelling from Des Moines Airport (DSM) to Florence Airport (FLR): what you need to know

The timezone in Florence is UTC+1, which is seven hours ahead of Des Moines.
Arriving two hours before an international flight and one hour ahead of a domestic departure are golden rules for hassle-free flying. Show up at the airport on time to catch your DSM to FLR flight.
During popular months such as August, it's a good idea to get to the airport earlier than normal. Plan to arrive two hours before a domestic departure and four hours ahead of an international flight whenever you're flying during a high season in general.

How to find the cheapest flights from Des Moines Airport (DSM) to Florence Airport (FLR)

At the moment, $890 is the cheapest price we've found for a one-way Des Moines Airport to Florence Airport flight. The best price for a return ticket is $1,550. Keep in mind that fares could change due to demand when booking.
To get your hands on cheap tickets from DSM to FLR, book early. Airlines tend to offer lower fares when flights are first released.
If you can be flexible with your travel plans, use the 'Whole month' tool. It'll give you the lowest price across the month when searching for a flight from Des Moines Airport to Florence Airport.
There's no need to check back in every day to see if fares have gone down when you set up a Price Alert. We'll send you an update as soon as there's a new deal on cheap flights from DSM to FLR.
Select your ideal arrival and departure times, number of stops and airlines with the filters. Alternatively, sort your results by 'Cheapest' to see the best deals on flights from Des Moines Airport to Florence Airport.

Handy information about Des Moines Airport (DSM)

The address for DSM is 5800 Fleur Drive, Suite 201.
77% of flights leaving from Des Moines Airport land at their destination on schedule.
Central Des Moines to Des Moines Airport is approximately 11 kilometres. Depending on traffic, it'll take about 15 minutes to get there if you're driving, ride-sharing or catching a taxi.
Planning to take public transport? Expect a journey time of around 30 minutes.
Searching for a handy hotel near DSM? If you've booked an early flight from Des Moines Airport to Florence Airport, these stays will have you moments from your departure lounge:

Arriving at Florence Airport (FLR)

Consider staying in a hotel close to FLR if you're catching a late Des Moines Airport to Florence Airport flight. Select one of these options and avoid the hassle of a long transfer:
Pick up a Florence Airport rental car and discover Florence and beyond with your own set of wheels. Surprice, Noleggiare and RentSmart24 are top outlets to choose from here.
Reserving your ride from Florence Airport around two weeks ahead boosts your odds of scoring a great price.

Getting from Florence Airport (FLR) to central Florence

Florence Airport is approximately 8 kilometres from central Florence. Driving there takes about 20 minutes.
It takes around 25 minutes if you're travelling on public transport.

When to fly to Florence Airport (FLR)

It's time to work out your trip dates for your flight from Des Moines Airport to Florence Airport. September is the most popular month to visit Florence. If you like a more low-key vibe, go in March.
Lock in your flight from Des Moines Airport to Florence Airport for August if you'd like to visit Florence during its warmest month. You can expect temperatures of between 14ºC and 35ºC.
Search for cheap tickets from DSM to FLR in January if you'd rather travel during cooler conditions. Temperatures are at their lowest then, ranging between -1ºC and 11ºC on average.

Explore more of Italy

You've done Florence, now it's time to explore more of Italy. Travel about 225 kilometres south-east to Rome to check off its top sights. From Vatican Museums to St. Peter's Basilica and Saint Peter's Square, there's plenty to keep you busy.
Milan is another favourite destination in Italy and is around 257 kilometres north-west of Florence. No trip is complete without dropping by Leonardo's Last Supper Museum, Teatro alla Scala and Milan Cathedral.