Cheap Flights from Des Moines to Rome from $1,368

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Flight deals from Des Moines to Rome

Looking for a cheap last-minute deal or the best return flight from Des Moines Airport to Rome? If you want to travel next month, return fares start from $1,548. Find the lowest prices on one-way and return tickets right here.

Rome.$1,368 per passenger.Departing Wed, 17 Mar, returning Wed, 31 Mar.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Wed, 17 Mar, arriving in Rome Fiumicino.Inbound indirect flight with Delta, departs from Rome Fiumicino on Wed, 31 Mar, arriving in Des Moines.Price includes taxes and charges.From $1,368, select.

Rome.$1,423 per passenger.Departing Wed, 12 Aug, returning Wed, 19 Aug.Return flight with United.Outbound indirect flight with United, departs from Des Moines on Wed, 12 Aug, arriving in Rome Fiumicino.Inbound indirect flight with United, departs from Rome Fiumicino on Wed, 19 Aug, arriving in Des Moines.Price includes taxes and charges.From $1,423, select.

Rome.$1,545 per passenger.Departing Sun, 19 Jul, returning Tue, 4 Aug.Return flight with KLM and Air France.Outbound indirect flight with KLM, departs from Des Moines on Sun, 19 Jul, arriving in Rome Fiumicino.Inbound indirect flight with Air France, departs from Rome Fiumicino on Tue, 4 Aug, arriving in Des Moines.Price includes taxes and charges.From $1,545, select.

Rome.$1,548 per passenger.Departing Tue, 21 Jul, returning Tue, 28 Jul.Return flight with United.Outbound indirect flight with United, departs from Des Moines on Tue, 21 Jul, arriving in Rome Fiumicino.Inbound indirect flight with United, departs from Rome Fiumicino on Tue, 28 Jul, arriving in Des Moines.Price includes taxes and charges.From $1,548, select.

Rome.$1,580 per passenger.Departing Thu, 1 Apr, returning Thu, 15 Apr.Return flight with United.Outbound indirect flight with United, departs from Des Moines on Thu, 1 Apr, arriving in Rome Fiumicino.Inbound indirect flight with United, departs from Rome Fiumicino on Thu, 15 Apr, arriving in Des Moines.Price includes taxes and charges.From $1,580, select.

Rome.$1,588 per passenger.Departing Wed, 14 Oct, returning Sat, 24 Oct.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Wed, 14 Oct, arriving in Rome Fiumicino.Inbound indirect flight with Delta, departs from Rome Fiumicino on Sat, 24 Oct, arriving in Des Moines.Price includes taxes and charges.From $1,588, select.

Rome.$1,697 per passenger.Departing Mon, 14 Sep, returning Sat, 19 Sep.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Mon, 14 Sep, arriving in Rome Fiumicino.Inbound indirect flight with Delta, departs from Rome Fiumicino on Sat, 19 Sep, arriving in Des Moines.Price includes taxes and charges.From $1,697, select.

Rome.$1,804 per passenger.Departing Sat, 21 Nov, returning Sat, 28 Nov.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Sat, 21 Nov, arriving in Rome Fiumicino.Inbound indirect flight with Delta, departs from Rome Fiumicino on Sat, 28 Nov, arriving in Des Moines.Price includes taxes and charges.From $1,804, select.

Rome.$1,857 per passenger.Departing Fri, 1 Jan, returning Sun, 10 Jan.Return flight with KLM and Air France.Outbound indirect flight with KLM, departs from Des Moines on Fri, 1 Jan, arriving in Rome Fiumicino.Inbound indirect flight with Air France, departs from Rome Fiumicino on Sun, 10 Jan, arriving in Des Moines.Price includes taxes and charges.From $1,857, select.

Rome.$1,873 per passenger.Departing Mon, 21 Dec, returning Wed, 30 Dec.Return flight with Air France.Outbound indirect flight with Air France, departs from Des Moines on Mon, 21 Dec, arriving in Rome Fiumicino.Inbound indirect flight with Air France, departs from Rome Fiumicino on Wed, 30 Dec, arriving in Des Moines.Price includes taxes and charges.From $1,873, select.

Rome.$2,386 per passenger.Departing Sun, 14 Jun, returning Wed, 24 Jun.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Sun, 14 Jun, arriving in Rome Fiumicino.Inbound indirect flight with Delta, departs from Rome Fiumicino on Wed, 24 Jun, arriving in Des Moines.Price includes taxes and charges.From $2,386, select.

Find the cheapest month to fly from Des Moines to Rome

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Des Moines to Rome flights are currently cheapest in March.

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Alternative Des Moines to Rome routes

Looking for the cheapest, fastest or easiest route from Des Moines to Rome? You could fly into the following airports instead.

Rome Ciampino

13km from central Rome

Closest

from $1,973

Search flights

Rome Fiumicino

23km from central Rome

Cheapest

from $1,368

Search flights

Des Moines to Rome: Flight information

The things to know before you go.

Cheapest flight found	$1,368
Cheapest month to fly	March

Finding cheap flights from Des Moines to Rome: Frequently asked questions

How many airports are there in Rome?

There are 2 airports in Rome: Rome Ciampino and Rome Fiumicino.

How much are return flights from Des Moines to Rome?

The best price we found for a return flight from Des Moines to Rome is $1,368. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

Which airlines fly direct from Des Moines to Rome?

Currently, there are no airlines that fly direct from Des Moines to Rome. But we found flights with one or more stops from $1,368.

How many flights are there a week from Des Moines to Rome?

As of June 2026, there are no flights flying from Des Moines to Rome.

When is the cheapest time to fly from Des Moines to Rome?

The cheapest month to fly from Des Moines to Rome is usually March.

Which is the cheapest airport to fly into in Rome?

If you're flying from Des Moines Airport, the cheapest airport near Rome is Rome Fiumicino – which is 22.9 km away from the centre of Rome. We've found flights into this airport from $1,368.

Which upcoming date is cheapest to fly from Des Moines Airport to Rome on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to Rome on Wednesday, 17 March 2027.

Can I get a direct flight from Des Moines Airport to Rome?

No airlines currently offer direct flights between Des Moines Airport and Rome. Most routes have one or more stops.

How can I get the best flight deal from Des Moines Airport to Rome?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Rome but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Rome?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Rome is around 40 days in advance, so don’t leave your flight to the last minute.

What’s the weather like in Rome?

In June, the average temperature is usually around 21°C. August is typically the warmest month in Rome, when it usually averages around 30°C. You can expect the least rain in July. The coldest month is January, with temperatures averaging 5°C. The rainiest month is November.

Which is the cheapest airline to fly from Des Moines Airport to Rome with?

Currently, Delta offers the cheapest flight tickets to Rome.

Flying from Des Moines International Airport (DSM) to Rome: what you need to know

Rome is seven hours ahead of Des Moines, where Des Moines International Airport is located. Rome follows the UTC+1 timezone.
For stress-free travel, turn up at the airport two hours ahead of international flights and one hour before domestic departures. This will give you enough time to catch your DSM to Rome flight.
During popular months such as July, it's a good idea to get to the airport earlier than usual. Arrive two hours before a domestic departure and four hours ahead of international flights when you travel during high season in general.
We make it easy to book plane tickets from DSM to Rome with a stopover. To see all the options, uncheck 'Direct flights only.' Then, select a flight offering a stop long enough to see the sights of the city of your choice. Top stopovers include:
- Chicago O'Hare International Airport (ORD)
- Atlanta Hartsfield-Jackson International Airport (ATL)
- Detroit Metropolitan Wayne County Airport (DTW)
DSM is about 6 kilometres from central Des Moines. If you're catching a taxi, driving or ride-sharing from the centre, it'll take you 15 minutes or so to get there, depending on the traffic. If you're planning to take public transport, expect the travel time to be around 30 minutes.
Booked an early flight from Des Moines International Airport to Rome? Avoid the last-minute rush to the terminal (and catch some extra z's) by choosing one of these stays near DSM:
77% of flights leaving from Des Moines International Airport land at their destination on schedule.
DSM's address is 5800 Fleur Drive, Suite 201.

How to find the cheapest flights from Des Moines International Airport (DSM) to Rome

$702 is the cheapest price we've seen for a one-way Des Moines International Airport to Rome flight. A round-trip plane ticket right now is $1,368. Depending on the availability when you book, these fares could change.
Booking in advance is often the key to scoring a cheap flight from DSM to Rome. Prices tend to rise as demand increases, so the nearer you get to departure, the more you'll likely pay.
If you're flexible with your travel plans, use the 'Whole month' tool. It'll give you the cheapest price across every month when searching for your Des Moines International Airport to Rome ticket.
There's no need to keep looking every day to find out if fares have dropped when you create a Price Alert. We'll update you when there's an extra saving on cheap flights from DSM to Rome.
Save money on your flight from Des Moines International Airport to Rome with the help of our filters. Choose your ideal times, number of stops and airlines, then sort the results by 'Cheapest' to see the best deals.

Airports in Rome

Rome Leonardo da Vinci Fiumicino Airport (FCO)

Rome Leonardo da Vinci Fiumicino Airport (FCO) to the centre of Rome takes around 40 minutes to reach by car. The centre is roughly 32 kilometres away.
When travelling by public transport, expect a journey time of around 30 minutes.
Think about booking a hotel close to FCO if you're coming in on a late flight from Des Moines International Airport to Rome. Select one of these options and make your first night all about rest:
Reserving your vehicle from Rome Leonardo da Vinci Fiumicino Airport around three weeks in advance of your flight from DSM to Rome can help you secure the lowest rate.

Rome Ciampino Airport (CIA)

After your flight from Des Moines International Airport to Rome has hit the runway, you can reach the city centre in about 20 minutes by car. Central Rome is roughly 14 kilometres from Rome Ciampino Airport (CIA).
You can expect the journey to take roughly 20 minutes on public transport.
Following your DSM to Rome flight, kick back at a hotel near CIA. These are some comfortable options that'll help you slip into relaxation mode:
Avoid potential price surges. Reserving your ride one week before your arrival at CIA will help you save.

Best time to go to Rome

December is the quietest month for flights from Des Moines International Airport to Rome, while August is the busiest. Pick the best time to visit Rome based on whether you prefer a laid-back vibe or a lively atmosphere.
Book a Des Moines International Airport to Rome plane ticket with a departure in August if you want to explore the city during its warmest month. Expect temperatures to range from 20ºC to 33ºC.
If you want to travel in cooler conditions, search for a cheap ticket from DSM to Rome in January when temperatures average between 2ºC and 14ºC.

More about Rome

When it comes to searching for somewhere to lay your head, you'll find the most popular stays in Rome right here. Check out these options once you've locked in your flight from Des Moines International Airport to Rome:
St. Peter's Basilica and Vatican Museums are just the start of the top-rated attractions to put on your Rome to-do list. Keep the momentum going by heading to Saint Peter's Square.

Explore more of Italy

You've done Rome, now it's time to explore other corners of Italy. Journey about 483 kilometres northwest to Milan to tick off its leading sights. From Leonardo's Last Supper Museum to Teatro alla Scala and Milan Cathedral, there's plenty to keep you on the go.
If you're interested in discovering another corner of Italy, consider Naples, about 193 kilometres southeast of Rome. Piazza del Plebiscito, Naples National Archaeological Museum and Gulf of Naples are among the biggest draws.