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Cheap Flights from Des Moines to San Diego International

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      Travellers and cabin class, 1 Adult, Economy

      Compare Des Moines to San Diego International flight deals

      Find the cheapest month or even day of the year to fly to San Diego International

      Book the best San Diego International fare with no extra fees

      Flight deals from Des Moines to San Diego International

      Looking for a cheap last-minute deal or the best return flight from Des Moines Airport to San Diego International Airport? If you want to travel next month, return fares start from $391. Find the lowest prices on one-way and return tickets right here.
      San Diego.$391 per passenger.Departing Mon, 9 Nov, returning Fri, 13 Nov.Return flight with Frontier Airlines.Outbound indirect flight with Frontier Airlines, departs from Des Moines on Mon, 9 Nov, arriving in San Diego International.Inbound indirect flight with Frontier Airlines, departs from San Diego International on Fri, 13 Nov, arriving in Des Moines.Price includes taxes and charges.From $391, select.
      San Diego.$451 per passenger.Departing Mon, 26 Oct, returning Mon, 2 Nov.Return flight with Frontier Airlines.Outbound indirect flight with Frontier Airlines, departs from Des Moines on Mon, 26 Oct, arriving in San Diego International.Inbound indirect flight with Frontier Airlines, departs from San Diego International on Mon, 2 Nov, arriving in Des Moines.Price includes taxes and charges.From $451, select.
      San Diego.$486 per passenger.Departing Fri, 23 Oct, returning Fri, 30 Oct.Return flight with Frontier Airlines.Outbound indirect flight with Frontier Airlines, departs from Des Moines on Fri, 23 Oct, arriving in San Diego International.Inbound indirect flight with Frontier Airlines, departs from San Diego International on Fri, 30 Oct, arriving in Des Moines.Price includes taxes and charges.From $486, select.
      San Diego.$596 per passenger.Departing Mon, 11 Jan, returning Fri, 15 Jan.Return flight with United.Outbound indirect flight with United, departs from Des Moines on Mon, 11 Jan, arriving in San Diego International.Inbound indirect flight with United, departs from San Diego International on Fri, 15 Jan, arriving in Des Moines.Price includes taxes and charges.From $596, select.
      San Diego.$622 per passenger.Departing Tue, 2 Feb, returning Tue, 16 Feb.Return flight with United.Outbound indirect flight with United, departs from Des Moines on Tue, 2 Feb, arriving in San Diego International.Inbound indirect flight with United, departs from San Diego International on Tue, 16 Feb, arriving in Des Moines.Price includes taxes and charges.From $622, select.
      San Diego.$622 per passenger.Departing Tue, 1 Dec, returning Tue, 15 Dec.Return flight with United.Outbound indirect flight with United, departs from Des Moines on Tue, 1 Dec, arriving in San Diego International.Inbound indirect flight with United, departs from San Diego International on Tue, 15 Dec, arriving in Des Moines.Price includes taxes and charges.From $622, select.
      San Diego.$622 per passenger.Departing Sat, 23 Jan, returning Sat, 6 Feb.Return flight with United.Outbound indirect flight with United, departs from Des Moines on Sat, 23 Jan, arriving in San Diego International.Inbound indirect flight with United, departs from San Diego International on Sat, 6 Feb, arriving in Des Moines.Price includes taxes and charges.From $622, select.
      San Diego.$630 per passenger.Departing Thu, 31 Dec, returning Sun, 3 Jan.Return flight with Frontier Airlines.Outbound indirect flight with Frontier Airlines, departs from Des Moines on Thu, 31 Dec, arriving in San Diego International.Inbound indirect flight with Frontier Airlines, departs from San Diego International on Sun, 3 Jan, arriving in Des Moines.Price includes taxes and charges.From $630, select.
      San Diego.$806 per passenger.Departing Mon, 26 Apr, returning Sat, 1 May.Return flight with Delta.Outbound indirect flight with Delta, departs from Des Moines on Mon, 26 Apr, arriving in San Diego International.Inbound indirect flight with Delta, departs from San Diego International on Sat, 1 May, arriving in Des Moines.Price includes taxes and charges.From $806, select.
      San Diego.$815 per passenger.Departing Mon, 22 Mar, returning Thu, 25 Mar.Return flight with United.Outbound indirect flight with United, departs from Des Moines on Mon, 22 Mar, arriving in San Diego International.Inbound indirect flight with United, departs from San Diego International on Thu, 25 Mar, arriving in Des Moines.Price includes taxes and charges.From $815, select.
      How did we find these deals? The deals you see here are the lowest prices for flight tickets from Des Moines to San Diego International found in the last 4 days, and are subject to change and availability.

      Find the cheapest month to fly from Des Moines to San Diego International

      We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Des Moines to San Diego International flights are currently cheapest in November.
      Oct
      from $486
      Nov
      from $391
      Dec
      from $622
      Jan
      from $596
      Feb
      from $622
      Mar
      from $815
      Apr
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      May
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      Jun
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      Jul
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      Aug
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      Sep
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      Des Moines to San Diego International: Alternative routes

      Compare routes from Des Moines to San Diego below. You may find an airport to fly into that's cheaper, faster, or easier than San Diego International.

      San Diego International

      4km from central San Diego
      ClosestCheapest
      from $391
      Search flights

      McClellan-Palomar

      48km from central San Diego
      from $1,310
      Search flights

      Des Moines to San Diego: Flight information

      The things to know before you go.
      Cheapest flight found$391
      Cheapest month to flyNovember

      Finding cheap flights from Des Moines to San Diego International: Frequently asked questions

      The best price we found for a return flight from Des Moines to San Diego International is $391. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
      Currently, there are no airlines that fly direct from Des Moines to San Diego International. But we found flights with one or more stops from $391.
      As of October 2026, there are no flights flying from Des Moines to San Diego International.
      The cheapest month to fly from Des Moines to San Diego International is usually November.
      After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Des Moines Airport to San Diego International Airport on Monday, 9 November 2026.
      No airlines currently offer direct flights between Des Moines Airport and San Diego International Airport. Most routes have one or more stops.
      We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to San Diego International but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

      We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to San Diego is around 40 days in advance, so don’t leave your flight to the last minute.

      Currently, Frontier Airlines offers the cheapest flight tickets to San Diego International.

      Travelling from Des Moines Airport (DSM) to San Diego International Airport (SAN): what you need to know

      • San Diego's timezone is UTC-8, which makes San Diego two hours behind Des Moines.

      • Give yourself enough time to make your DSM to SAN flight. A good rule of thumb is to arrive two hours before international departures and an hour ahead for domestic flights.

      • You'll likely experience longer lines in popular months such as August. Arriving up to four hours in advance for an international flight and two hours for domestic departures is a wise move.

      • If you want to include a stop along the way, just uncheck 'Direct flights only' when searching for your ticket from Des Moines Airport to San Diego International Airport. These are the most popular stopovers between DSM and SAN:

        • Denver International Airport

        • Phoenix Sky Harbour Airport

        • Harry Reid International Airport

      Handy information about Des Moines Airport (DSM)

      • The address for DSM is 5800 Fleur Drive, Suite 201.

      • When it comes to Des Moines Airport's on-time performance, 77% of flights arrive within the scheduled timeframe.

      • Central Des Moines to Des Moines Airport is approximately 11 kilometres. Depending on traffic, it'll take you about 15 minutes to get there if you're ride-sharing, catching a taxi or driving.

      • Planning to catch public transport? You can expect a journey time of around 30 minutes.

      • Booked an early flight from Des Moines Airport to San Diego International Airport? Avoid the hassle of rushing to the terminal (and enjoy a little extra shut-eye) by picking one of these stays close to DSM:

      Arriving at San Diego International Airport (SAN)

      When to fly to San Diego International Airport (SAN)

      • August is the most popular month for flights from Des Moines Airport to San Diego International Airport. To avoid the crowds, travel to San Diego in March.

      • Before locking in your flight from Des Moines Airport to San Diego International Airport, think about the type of weather you enjoy. August is the warmest month in San Diego, with the temperature ranging from 16ºC to 27ºC.

      • February sees average temperatures of between 8ºC and 22ºC. Search for cheap tickets from DSM to SAN sometime then if you like cooler conditions.

      Explore more of the United States

      • San Diego is easy to fall in love with, but there are so many other corners of the United States you should also see. Around 177 kilometres north-west of San Diego, a trip to Los Angeles will keep your itinerary busy. Start with leading attractions like Hollywood Sign, Universal Studios Hollywood and Hollywood Bowl.

      • Phoenix is another sought-after destination in the United States and is around 483 kilometres east of San Diego. No trip is complete without dropping by Camelback Mountain, Yayoi Kusama Fireflies Infinity Mirror Room and Heard Museum.

      More travel options

      Plan the rest of your trip from Des Moines to San Diego

      Prices shown on this page are estimated lowest prices only. Found in the last 12 days.