Cheap Flights from Minneapolis St Paul to Knoxville

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Compare Minneapolis St Paul to Knoxville flight deals

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Flight deals from Minneapolis St Paul to Knoxville

Looking for a cheap last-minute deal or the best return flight from Minneapolis St Paul Airport to Knoxville Airport? If you want to travel next month, return fares start from $588. Find the lowest prices on one-way and return tickets right here.

Knoxville.$463 per passenger.Departing Fri, 13 Nov, returning Mon, 16 Nov.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from Minneapolis St Paul on Fri, 13 Nov, arriving in Knoxville.Inbound indirect flight with Southwest Airlines, departs from Knoxville on Mon, 16 Nov, arriving in Minneapolis St Paul.Price includes taxes and charges.From $463, select.

Knoxville.$515 per passenger.Departing Fri, 12 Feb, returning Fri, 26 Feb.Return flight with Delta.Outbound direct flight with Delta departs from Minneapolis St Paul on Fri, 12 Feb, arriving in Knoxville.Inbound direct flight with Delta departs from Knoxville on Fri, 26 Feb, arriving in Minneapolis St Paul.Price includes taxes and charges.From $515, select.

Knoxville.$515 per passenger.Departing Fri, 8 Jan, returning Fri, 22 Jan.Return flight with Delta.Outbound direct flight with Delta departs from Minneapolis St Paul on Fri, 8 Jan, arriving in Knoxville.Inbound direct flight with Delta departs from Knoxville on Fri, 22 Jan, arriving in Minneapolis St Paul.Price includes taxes and charges.From $515, select.

Knoxville.$532 per passenger.Departing Fri, 11 Dec, returning Fri, 25 Dec.Return flight with Delta.Outbound indirect flight with Delta, departs from Minneapolis St Paul on Fri, 11 Dec, arriving in Knoxville.Inbound indirect flight with Delta, departs from Knoxville on Fri, 25 Dec, arriving in Minneapolis St Paul.Price includes taxes and charges.From $532, select.

Knoxville.$549 per passenger.Departing Thu, 29 Oct, returning Mon, 2 Nov.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from Minneapolis St Paul on Thu, 29 Oct, arriving in Knoxville.Inbound indirect flight with Southwest Airlines, departs from Knoxville on Mon, 2 Nov, arriving in Minneapolis St Paul.Price includes taxes and charges.From $549, select.

Knoxville.$549 per passenger.Departing Fri, 5 Mar, returning Tue, 9 Mar.Return flight with Delta.Outbound direct flight with Delta departs from Minneapolis St Paul on Fri, 5 Mar, arriving in Knoxville.Inbound direct flight with Delta departs from Knoxville on Tue, 9 Mar, arriving in Minneapolis St Paul.Price includes taxes and charges.From $549, select.

Knoxville.$550 per passenger.Departing Fri, 4 Dec, returning Wed, 9 Dec.Return flight with Delta.Outbound direct flight with Delta departs from Minneapolis St Paul on Fri, 4 Dec, arriving in Knoxville.Inbound direct flight with Delta departs from Knoxville on Wed, 9 Dec, arriving in Minneapolis St Paul.Price includes taxes and charges.From $550, select.

Knoxville.$551 per passenger.Departing Thu, 12 Nov, returning Mon, 16 Nov.Return flight with Delta.Outbound direct flight with Delta departs from Minneapolis St Paul on Thu, 12 Nov, arriving in Knoxville.Inbound direct flight with Delta departs from Knoxville on Mon, 16 Nov, arriving in Minneapolis St Paul.Price includes taxes and charges.From $551, select.

Knoxville.$554 per passenger.Departing Wed, 7 Jul, returning Sat, 10 Jul.Return flight with Delta.Outbound direct flight with Delta departs from Minneapolis St Paul on Wed, 7 Jul, arriving in Knoxville.Inbound direct flight with Delta departs from Knoxville on Sat, 10 Jul, arriving in Minneapolis St Paul.Price includes taxes and charges.From $554, select.

Knoxville.$571 per passenger.Departing Thu, 26 Nov, returning Tue, 1 Dec.Return flight with Delta.Outbound indirect flight with Delta, departs from Minneapolis St Paul on Thu, 26 Nov, arriving in Knoxville.Inbound indirect flight with Delta, departs from Knoxville on Tue, 1 Dec, arriving in Minneapolis St Paul.Price includes taxes and charges.From $571, select.

Knoxville.$584 per passenger.Departing Fri, 9 Apr, returning Fri, 23 Apr.Return flight with Delta.Outbound direct flight with Delta departs from Minneapolis St Paul on Fri, 9 Apr, arriving in Knoxville.Inbound direct flight with Delta departs from Knoxville on Fri, 23 Apr, arriving in Minneapolis St Paul.Price includes taxes and charges.From $584, select.

Knoxville.$588 per passenger.Departing Sat, 17 Oct, returning Tue, 20 Oct.Return flight with United.Outbound indirect flight with United, departs from Minneapolis St Paul on Sat, 17 Oct, arriving in Knoxville.Inbound indirect flight with United, departs from Knoxville on Tue, 20 Oct, arriving in Minneapolis St Paul.Price includes taxes and charges.From $588, select.

Knoxville.$636 per passenger.Departing Sat, 26 Jun, returning Sat, 3 Jul.Return flight with Delta.Outbound indirect flight with Delta, departs from Minneapolis St Paul on Sat, 26 Jun, arriving in Knoxville.Inbound indirect flight with Delta, departs from Knoxville on Sat, 3 Jul, arriving in Minneapolis St Paul.Price includes taxes and charges.From $636, select.

Knoxville.$685 per passenger.Departing Thu, 6 May, returning Sun, 9 May.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from Minneapolis St Paul on Thu, 6 May, arriving in Knoxville.Inbound indirect flight with Southwest Airlines, departs from Knoxville on Sun, 9 May, arriving in Minneapolis St Paul.Price includes taxes and charges.From $685, select.

Knoxville.$687 per passenger.Departing Fri, 2 Oct, returning Mon, 5 Oct.Return flight with Delta.Outbound direct flight with Delta departs from Minneapolis St Paul on Fri, 2 Oct, arriving in Knoxville.Inbound direct flight with Delta departs from Knoxville on Mon, 5 Oct, arriving in Minneapolis St Paul.Price includes taxes and charges.From $687, select.

Knoxville.$739 per passenger.Departing Fri, 14 May, returning Fri, 28 May.Return flight with Delta.Outbound direct flight with Delta departs from Minneapolis St Paul on Fri, 14 May, arriving in Knoxville.Inbound direct flight with Delta departs from Knoxville on Fri, 28 May, arriving in Minneapolis St Paul.Price includes taxes and charges.From $739, select.

Find the cheapest month to fly from Minneapolis St Paul to Knoxville

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Minneapolis St Paul to Knoxville flights are currently cheapest in November.

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Direct flights from Minneapolis St Paul to Knoxville

Minneapolis St Paul to Knoxville: Alternative routes

Compare routes from Minneapolis St Paul to Knoxville below. You may find an airport to fly into that's cheaper, faster, or easier than Knoxville.

Knoxville

18km from central Knoxville

ClosestCheapest

from $463

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Minneapolis to Knoxville: Flight information

The things to know before you go.

Cheapest flight found	$463
Cheapest month to fly	November
Average flight time	2 hrs, 19 mins
Most popular airline	KLM
Average flights per week	52

Finding cheap flights from Minneapolis St Paul to Knoxville: Frequently asked questions

How much are return flights from Minneapolis St Paul to Knoxville?

The best price we found for a return flight from Minneapolis St Paul to Knoxville is $463. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

How long does it take to fly from Minneapolis St Paul to Knoxville?

2 hours and 19 minutes is the average flight time from Minneapolis St Paul to Knoxville.

Which airlines fly direct from Minneapolis St Paul to Knoxville?

KLM, Delta and Endeavor Air fly direct from Minneapolis St Paul to Knoxville.

How many flights are there a week from Minneapolis St Paul to Knoxville?

As of September 2026, there are 52 flights per week flying from Minneapolis St Paul to Knoxville.

When is the cheapest time to fly from Minneapolis St Paul to Knoxville?

The cheapest month to fly from Minneapolis St Paul to Knoxville is usually November.

Which upcoming date is cheapest to fly from Minneapolis St Paul Airport to Knoxville Airport on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Minneapolis St Paul Airport to Knoxville Airport on Friday, 13 November 2026.

Can I get a direct flight from Minneapolis St Paul Airport to Knoxville Airport?

Yes – the average flight time is 2 hours and 19 minutes.

How can I find the best flight deal to Knoxville?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Knoxville but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Knoxville?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Knoxville is around 40 days in advance, so don’t leave your flight to the last minute.

Which is the cheapest airline to fly from Minneapolis St Paul Airport to Knoxville with?

Currently, Southwest Airlines and Delta offer the cheapest flight tickets to Knoxville.

Flying from Minneapolis St Paul Airport (MSP) to Knoxville Airport (TYS): what you need to know

Take a direct flight from Minneapolis St Paul Airport to Knoxville Airport and you'll be travelling for an average of 2 hours 15 minutes.
Flights from MSP to TYS start from 13:30 — the first with Delta Air Lines. The last service of the day is at 19:59 with Delta Air Lines. Overall, you can choose from ten weekly Minneapolis St Paul Airport to Knoxville Airport flights.
To ensure you get on your MSP to TYS flight, allow plenty of time for things like baggage drop and finding your gate. Arriving two hours ahead of international departures and an hour before domestic flights is the standard rule.
During popular months like July, it's best to get to the airport even earlier. Plan to arrive two hours before domestic departures and four hours ahead of an international flight whenever you're travelling during peak periods in general.
Delta is your ticket to exploring Knoxville (and maybe even some other exciting parts of the United States!). Browse the direct flights from Minneapolis St Paul Airport to Knoxville Airport offered by this airline.
Delta is the airline with the highest passenger demand for this route.
With 72.29% of its services arriving as scheduled, Delta is the most punctual carrier offering MSP to TYS flights.
We make it easy to book a flight with a stopover. To see all your options for tickets from Minneapolis St Paul Airport to Knoxville Airport, uncheck 'Direct flights only.' Then, pick a flight with a stop long enough to explore the city of your choice. Top stopovers between MSP and TYS include:
- Chicago O'Hare International Airport
- Detroit Wayne County Airport
- Chicago Midway Airport

How to find the cheapest flights from Minneapolis St Paul Airport (MSP) to Knoxville Airport (TYS)

Currently, $343 is the cheapest price we've found for a one-way Minneapolis St Paul Airport to Knoxville Airport flight. The best price for a return plane ticket is $463. Remember that fares may change due to availability at the time of booking.
Get cheap tickets from MSP to TYS by booking three months ahead. According to our research, that's the sweet spot for landing a bargain.
The cheapest month for flights from Minneapolis St Paul Airport to Knoxville Airport is August. Use the 'Whole month' tool to find the lowest prices if you have flexible travel dates.
You don't need to check back in every day to find out if fares have dropped when you create a Price Alert. We'll let you know the moment a special offer becomes available on cheap flights from MSP to TYS.
Tailor your flights using filters. Pick your preferred arrival and departure times, airlines and total journey duration. You can also sort the results by 'Cheapest,' 'Fastest' or 'Best' flights from Minneapolis St Paul Airport to Knoxville Airport.

Handy information about Minneapolis St Paul Airport (MSP)

You'll find MSP at 6040 28th Avenue South.
77% of flights leaving from Minneapolis St Paul Airport touch down at their destination on schedule.
To reach Minneapolis St Paul Airport from central Minneapolis, it takes around 20 minutes if you're planning to drive. Of course, this depends on traffic conditions. It's approximately 18 kilometres from the airport to the city centre.
You can expect a trip time of about 25 minutes when using public transport.
Booked an early flight from Minneapolis St Paul Airport to Knoxville Airport? Avoid rushing to the terminal (and catch some extra z's) by choosing one of these hotels near MSP:

Arriving at Knoxville Airport (TYS)

The last thing you need is a long journey to your hotel if you're landing late on a Minneapolis St Paul Airport to Knoxville Airport flight. Reserve one of these accommodation options near TYS instead:
Pick up a Knoxville Airport rental car and explore Knoxville and beyond with your own set of wheels. Budget, Alamo and Avis are top providers you can book with here.
To secure the lowest price, book your ride from Knoxville Airport about three weeks ahead.

When to fly to Knoxville Airport (TYS)

The quietest month for a flight from Minneapolis St Paul Airport to Knoxville Airport is March, while October is the busiest. Choose the ideal time to visit Knoxville based on whether you prefer a faster pace or a more relaxed vibe.
The warmest month in Knoxville is July, with the temperature ranging between 17ºC and 32ºC. Lock in your flights from Minneapolis St Paul Airport to Knoxville Airport in this month if you like this kind of weather.
Look for cheap tickets from MSP to TYS in January if you want to travel in cooler conditions. Temperatures are at their lowest around then, ranging between -6ºC and 11ºC on average.

Explore more of the United States

Knoxville has plenty to offer, but there are so many other corners of the United States just waiting to be explored. About 451 kilometres north of Knoxville, a visit to Columbus will keep you on the go. Don't miss top attractions like Franklin Park Conservatory and Botanical Gardens, Whetstone Park / Park of Roses and Ohio Theatre.
Indianapolis is another standout destination in the United States and is around 467 kilometres north-west of Knoxville. No trip is complete without seeing Lucas Oil Stadium, Eiteljorg Museum and The Children's Museum of Indianapolis.