Cheap Flights from Panama City to Santo Domingo

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Flight deals from Panama City to Santo Domingo

Looking for a cheap last-minute deal or the best return flight from Panama City to Santo Domingo? If you want to travel next month, return fares start from $946. Find the lowest prices on one-way and return tickets right here.

Santo Domingo.$932 per passenger.Departing Sat, 28 Nov, returning Fri, 8 Jan.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Sat, 28 Nov, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Fri, 8 Jan, arriving in Panama City Tocumen International.Price includes taxes and charges.From $932, select.

Santo Domingo.$938 per passenger.Departing Mon, 1 Feb, returning Thu, 11 Feb.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 1 Feb, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Thu, 11 Feb, arriving in Panama City Tocumen International.Price includes taxes and charges.From $938, select.

Santo Domingo.$946 per passenger.Departing Sun, 23 Aug, returning Mon, 31 Aug.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Sun, 23 Aug, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Mon, 31 Aug, arriving in Panama City Tocumen International.Price includes taxes and charges.From $946, select.

Santo Domingo.$946 per passenger.Departing Thu, 14 Jan, returning Thu, 21 Jan.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Thu, 14 Jan, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Thu, 21 Jan, arriving in Panama City Tocumen International.Price includes taxes and charges.From $946, select.

Santo Domingo.$946 per passenger.Departing Wed, 14 Oct, returning Fri, 16 Oct.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Wed, 14 Oct, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Fri, 16 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From $946, select.

Santo Domingo.$946 per passenger.Departing Sat, 28 Nov, returning Fri, 8 Jan.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sat, 28 Nov, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Fri, 8 Jan, arriving in Panama City Tocumen International.Price includes taxes and charges.From $946, select.

Santo Domingo.$946 per passenger.Departing Mon, 15 Mar, returning Mon, 22 Mar.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Mon, 15 Mar, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Mon, 22 Mar, arriving in Panama City Tocumen International.Price includes taxes and charges.From $946, select.

Santo Domingo.$946 per passenger.Departing Sun, 22 Nov, returning Sun, 21 Feb.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Sun, 22 Nov, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Sun, 21 Feb, arriving in Panama City Tocumen International.Price includes taxes and charges.From $946, select.

Santo Domingo.$946 per passenger.Departing Sat, 17 Oct, returning Sat, 24 Oct.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sat, 17 Oct, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sat, 24 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From $946, select.

Santo Domingo.$946 per passenger.Departing Fri, 18 Sep, returning Fri, 25 Sep.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 18 Sep, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Fri, 25 Sep, arriving in Panama City Tocumen International.Price includes taxes and charges.From $946, select.

Santo Domingo.$946 per passenger.Departing Sat, 3 Apr, returning Mon, 12 Apr.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Sat, 3 Apr, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Mon, 12 Apr, arriving in Panama City Tocumen International.Price includes taxes and charges.From $946, select.

Santo Domingo.$946 per passenger.Departing Fri, 30 Oct, returning Tue, 3 Nov.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Fri, 30 Oct, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Tue, 3 Nov, arriving in Panama City Tocumen International.Price includes taxes and charges.From $946, select.

Santo Domingo.$946 per passenger.Departing Sat, 26 Dec, returning Sun, 3 Jan.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sat, 26 Dec, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sun, 3 Jan, arriving in Panama City Tocumen International.Price includes taxes and charges.From $946, select.

Santo Domingo.$946 per passenger.Departing Mon, 1 Feb, returning Thu, 11 Feb.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Mon, 1 Feb, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Thu, 11 Feb, arriving in Panama City Tocumen International.Price includes taxes and charges.From $946, select.

Santo Domingo.$946 per passenger.Departing Wed, 19 Aug, returning Wed, 21 Oct.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Wed, 19 Aug, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Wed, 21 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From $946, select.

Santo Domingo.$948 per passenger.Departing Wed, 24 Feb, returning Wed, 3 Mar.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Wed, 24 Feb, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Wed, 3 Mar, arriving in Panama City Tocumen International.Price includes taxes and charges.From $948, select.

Find the cheapest month to fly from Panama City to Santo Domingo

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Panama City to Santo Domingo flights are currently cheapest in February.

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Direct flights from Panama City to Santo Domingo

Alternative Panama City to Santo Domingo routes

Looking for the cheapest, fastest or easiest route from Panama City to Santo Domingo? You could fly into the following airports instead.

Panama City to Santo Domingo: Flight information

The things to know before you go.

Cheapest flight found	$932
Cheapest month to fly	November
Average flight time	2 hrs, 27 mins
Most popular airline	Copa
Average flights per week	74

Finding cheap flights from Panama City to Santo Domingo: Frequently asked questions

How many airports are there in Santo Domingo?

There are 3 airports in Santo Domingo: La Isabela International, Santo Domingo Las Americas and Samana.

How much are return flights from Panama City to Santo Domingo?

The best price we found for a return flight from Panama City to Santo Domingo is $932. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

How long does it take to fly from Panama City to Santo Domingo?

2 hours and 27 minutes is the average flight time from Panama City to Santo Domingo.

Which airlines fly direct from Panama City to Santo Domingo?

Copa, KLM and Air France fly direct from Panama City to Santo Domingo.

How many flights are there a week from Panama City to Santo Domingo?

As of July 2026, there are 72 flights per week flying from Panama City to Santo Domingo.

When is the cheapest time to fly from Panama City to Santo Domingo?

The cheapest month to fly from Panama City to Santo Domingo is usually November.

Which is the cheapest airport to fly into in Santo Domingo?

If you're flying from Panama City, the cheapest airport near Santo Domingo is Santo Domingo Las Americas – which is 23.4 km away from the centre of Santo Domingo. We've found flights into this airport from $932.

Which upcoming date is cheapest to fly from Panama City to Santo Domingo on?

After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Panama City to Santo Domingo on Saturday, 28 November 2026.

Can I get a direct flight from Panama City to Santo Domingo?

Yes – the average flight time is 2 hours and 27 minutes.

How can I get the best flight deal from Panama City to Santo Domingo?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Santo Domingo but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Santo Domingo?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Santo Domingo is around 40 days in advance, so don’t leave your flight to the last minute.

What’s the weather like in Santo Domingo?

In July, the average temperature is usually around 28°C. August is typically the warmest month in Santo Domingo, when it usually averages around 31°C. You can expect the least rain in March. The coldest month is January, with temperatures averaging 21°C. The rainiest month is September.

Which is the cheapest airline to fly from Panama City to Santo Domingo with?

The cheapest airline that flies to Santo Domingo is Avianca. And the cheapest airline that flies to Santo Domingo Las Americas Airport is Copa.

Travelling from Panama City to Santo Domingo: what you need to know

There are a couple of main airports to choose from in Panama City. Check out your options departing from Panama City Tocumen International Airport (PTY) or Balboa Airport (BLB) when reserving your flight from Panama City to Santo Domingo.
When working out where to arrive in Santo Domingo, Santo Domingo Las Americas Airport (SDQ) and La Isabela International Airport (JBQ) are the primary gateways.
Around 2 hours 30 minutes is how long you'll be travelling on a direct Panama City to Santo Domingo flight.
Santo Domingo is one hour ahead of Panama City and observes the UTC-4 timezone.
Panama City Tocumen International Airport (PTY) to Santo Domingo Las Americas Airport (SDQ) is the most popular route that connects these two cities. There are 34 departures a week to choose from. If you prefer starting your day later, the last flight from Panama City to Santo Domingo is with Copa Airlines at 23:13. Choose the first PTY to SDQ departure with Copa Airlines at 07:18 to make the most of your arrival in Santo Domingo.
To ensure you board your Panama City to Santo Domingo flight, allow plenty of time to check in and drop off your luggage. Arriving two hours before international departures and one hour before domestic flights is the general travel rule.
During popular months like July, it's best to get to the airport well in advance. Arrive two hours before domestic departures and four hours ahead of international flights whenever you're flying during high season in general.

How to find the cheapest flights from Panama City to Santo Domingo

To score cheap Panama City to Santo Domingo flights, book your trip 11 months ahead of your planned departure.
Organise your trip for April. That's the best month for scoring an incredible deal on plane tickets from Panama City to Santo Domingo. If you have flexibility with your dates, use the 'Whole month' tool to find the lowest price across each month.
There's no need to search every day to find out if prices have dropped when you create a Price Alert. We'll notify you when a better deal comes up on cheap flights from Panama City to Santo Domingo.
Find a cheap Panama City to Santo Domingo flight with the help of our filters. Select your ideal duration, number of stops and airlines, then sort the results by 'Cheapest' to see the best deals.

Flying from Panama City

Panama City Tocumen International Airport (PTY)

If you're looking for a direct flight from Panama City to Santo Domingo, you can leave from Panama City Tocumen International Airport (PTY). Fly from PTY to Santo Domingo Las Americas Airport (SDQ) without making any stops.
Keep an eye out for deals with Copa Airlines. This airline offers direct Panama City to Santo Domingo plane tickets out of PTY.
We make it a cinch to find a Panama City to Santo Domingo flight with a stopover. To see all your options departing from Panama City Tocumen International Airport, deselect 'Direct flights only.' Then, pick a flight offering a stop long enough to see the sights of the city of your choice. Major stopovers include:
- Miami International Airport (MIA)
- San Juan Luis Munoz Marin Airport (SJU)
- Oranjestad Airport (AUA)
The journey from central Panama City to PTY takes about 50 minutes by public transport. If you drive, ride-share or grab a taxi, you'll cover the 18 kilometres in 35 minutes or so, depending on traffic conditions.
Have an early flight from Panama City to Santo Domingo? Avoid rushing to the terminal (and enjoy a little extra shut-eye) by choosing one of these stays close to Panama City Tocumen International Airport:
Panama City Tocumen International Airport maintains a strong on-time record, so you're less likely to experience disruptions. Departures from PTY land at their destination as scheduled 88% of the time.

Balboa Airport (BLB)

Visit friends or family or just take some time to unwind with a stopover. If you'd like to break up your Panama City to Santo Domingo flight, here's where you can stop when leaving from Balboa Airport:
- Bogota Airport (BOG)
- San Jose Juan Santamaria Airport (SJO)
- Cartagena Airport (CTG)
You can get to BLB from central Panama City in about 10 minutes by car (depending on traffic). The journey on public transport takes roughly 20 minutes to cover the 5 kilometres or so.
You're off on holiday, so why not spend an extra night away from home? Think about staying at one of these accommodation options near Balboa Airport the day before your flight from Panama City to Santo Domingo:
Balboa Airport has a strong track record for reliability and timeliness. 88% of flights leaving here meet their scheduled arrival times without fail.

Arriving in Santo Domingo

Santo Domingo Las Americas Airport (SDQ)

The distance from Santo Domingo Las Americas Airport (SDQ) to central Santo Domingo is roughly 24 kilometres. It'll take you around 35 minutes to get to the centre driving.
Getting to the centre by public transport will take you roughly 1 hour 15 minutes.
The last thing you need is a long journey to your hotel if you're arriving on a late flight from Panama City to Santo Domingo. Check in to one of these accommodation options near SDQ instead:
Hit the road running by picking up a Santo Domingo Las Americas Airport rental car. Grab your wheels from Final Rentals, FlexWays or INFINITY RENT and experience the lesser-explored corners of Santo Domingo and beyond.
Booking your vehicle from Santo Domingo Las Americas Airport about one week ahead increases your chances of getting a good deal.

La Isabela International Airport (JBQ)

After your flight from Panama City to Santo Domingo has arrived, you can get to the city centre in around 30 minutes by car. Central Santo Domingo is roughly 14 kilometres from La Isabela International Airport (JBQ).
You can expect the trip to take roughly 50 minutes on public transport.
Hang up the 'Do not disturb' sign and rest at a hotel near JBQ. Here are a few options where you can settle in after your flight from Panama City to Santo Domingo:
Crank up the tunes and hit the road in a La Isabela International Airport rental car. Pick up a set of wheels from FlexWays and begin discovering new places right away.
Get the vehicle you prefer, not just what's left, by securing your ride from JBQ ahead of your arrival. You'll also avoid paying extra, especially during busy airport times.

Best time to go to Santo Domingo

July is the busiest month for flights from Panama City to Santo Domingo. To skip the crowds, go to Santo Domingo in March.
The warmest month in Santo Domingo is September, with temperatures ranging between 23ºC and 33ºC. Lock in your Panama City to Santo Domingo ticket then if that's your ideal forecast.
February has average temperatures of between 19ºC and 29ºC. Look for cheap flights from Panama City to Santo Domingo around that time if you like travelling in cooler conditions.

More about Santo Domingo

Once you've booked your flight from Panama City to Santo Domingo, decide where you'll be dropping your bags. Make one of these options your base for exploring Santo Domingo:
There are so many things to do and see in this city it can be tricky to work out where to start. Alcazar de Colon, Nacional Botanical Garden and Fortress of Columbus are highlights which should feature on any well-planned Santo Domingo itinerary.

Explore more of the Dominican Republic

You've done Santo Domingo, now it's time to discover more of the Dominican Republic. Travel around 2 kilometres northeast to Santo Domingo Este to check off its leading sights. From Lago los tres ojos to Dominican Republic National Aquarium and La Cueva del Eden, you'll have a packed itinerary ahead.
San Pedro de Macorís is another standout destination in the Dominican Republic and is around 64 kilometres east of Santo Domingo. No journey is complete without experiencing Pedro Mir Ecological Park, San Pedro de Macoris Boardwalk and Centro Cultural Macorisano.