Cheap Flights from Panama City to Santo Domingo

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Flight deals from Panama City to Santo Domingo

Looking for a cheap last-minute deal or the best return flight from Panama City to Santo Domingo? If you want to travel next month, return fares start from $891. Find the lowest prices on one-way and return tickets right here.

Santo Domingo.$803 per passenger.Departing Fri, 3 Jul, returning Sat, 18 Jul.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 3 Jul, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Sat, 18 Jul, arriving in Panama City Tocumen International.Price includes taxes and charges.From $803, select.

Santo Domingo.$804 per passenger.Departing Wed, 10 Jun, returning Sat, 18 Jul.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Wed, 10 Jun, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Sat, 18 Jul, arriving in Panama City Tocumen International.Price includes taxes and charges.From $804, select.

Santo Domingo.$804 per passenger.Departing Fri, 5 Jun, returning Fri, 12 Jun.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 5 Jun, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Fri, 12 Jun, arriving in Panama City Tocumen International.Price includes taxes and charges.From $804, select.

Santo Domingo.$805 per passenger.Departing Sun, 7 Jun, returning Wed, 10 Jun.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sun, 7 Jun, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Wed, 10 Jun, arriving in Panama City Tocumen International.Price includes taxes and charges.From $805, select.

Santo Domingo.$806 per passenger.Departing Fri, 3 Jul, returning Sat, 18 Jul.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Fri, 3 Jul, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sat, 18 Jul, arriving in Panama City Tocumen International.Price includes taxes and charges.From $806, select.

Santo Domingo.$806 per passenger.Departing Wed, 10 Jun, returning Sat, 18 Jul.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Wed, 10 Jun, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sat, 18 Jul, arriving in Panama City Tocumen International.Price includes taxes and charges.From $806, select.

Santo Domingo.$850 per passenger.Departing Sat, 23 May, returning Sat, 13 Jun.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Sat, 23 May, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Sat, 13 Jun, arriving in Panama City Tocumen International.Price includes taxes and charges.From $850, select.

Santo Domingo.$854 per passenger.Departing Thu, 9 Jul, returning Thu, 20 Aug.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Thu, 9 Jul, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Thu, 20 Aug, arriving in Panama City Tocumen International.Price includes taxes and charges.From $854, select.

Santo Domingo.$856 per passenger.Departing Sat, 18 Jul, returning Wed, 5 Aug.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sat, 18 Jul, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Wed, 5 Aug, arriving in Panama City Tocumen International.Price includes taxes and charges.From $856, select.

Santo Domingo.$891 per passenger.Departing Thu, 30 Apr, returning Fri, 8 May.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Thu, 30 Apr, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Fri, 8 May, arriving in Panama City Tocumen International.Price includes taxes and charges.From $891, select.

Santo Domingo.$891 per passenger.Departing Sat, 2 May, returning Fri, 8 May.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Sat, 2 May, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Fri, 8 May, arriving in Panama City Tocumen International.Price includes taxes and charges.From $891, select.

Santo Domingo.$895 per passenger.Departing Tue, 15 Sep, returning Wed, 23 Sep.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Tue, 15 Sep, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Wed, 23 Sep, arriving in Panama City Tocumen International.Price includes taxes and charges.From $895, select.

Santo Domingo.$895 per passenger.Departing Tue, 6 Oct, returning Tue, 20 Oct.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Tue, 6 Oct, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Tue, 20 Oct, arriving in Panama City Tocumen International.Price includes taxes and charges.From $895, select.

Santo Domingo.$895 per passenger.Departing Sat, 22 Aug, returning Sat, 29 Aug.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Sat, 22 Aug, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Sat, 29 Aug, arriving in Panama City Tocumen International.Price includes taxes and charges.From $895, select.

Santo Domingo.$895 per passenger.Departing Wed, 25 Nov, returning Wed, 9 Dec.Return flight with Copa.Outbound direct flight with Copa departs from Panama City Tocumen International on Wed, 25 Nov, arriving in Santo Domingo Las Americas.Inbound direct flight with Copa departs from Santo Domingo Las Americas on Wed, 9 Dec, arriving in Panama City Tocumen International.Price includes taxes and charges.From $895, select.

Santo Domingo.$896 per passenger.Departing Mon, 1 Mar, returning Mon, 8 Mar.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 1 Mar, arriving in Santo Domingo Las Americas.Inbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Mon, 8 Mar, arriving in Panama City Tocumen International.Price includes taxes and charges.From $896, select.

Find the cheapest month to fly from Panama City to Santo Domingo

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Panama City to Santo Domingo flights are currently cheapest in July.

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Direct flights from Panama City to Santo Domingo

Alternative Panama City to Santo Domingo routes

Looking for the cheapest, fastest or easiest route from Panama City to Santo Domingo? You could fly into the following airports instead.

Panama City to Santo Domingo: Flight information

The things to know before you go.

Cheapest flight found	$803
Cheapest month to fly	July
Average flight time	2 hrs, 28 mins
Most popular airline	Copa
Average flights per week	80

Finding cheap flights from Panama City to Santo Domingo: Frequently asked questions

How many airports are there in Santo Domingo?

There are 3 airports in Santo Domingo: La Isabela International, Santo Domingo Las Americas and Samana.

How much are return flights from Panama City to Santo Domingo?

The best price we found for a return flight from Panama City to Santo Domingo is $803. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

How long does it take to fly from Panama City to Santo Domingo?

2 hours and 28 minutes is the average flight time from Panama City to Santo Domingo.

Which airlines fly direct from Panama City to Santo Domingo?

Copa, KLM and Air France fly direct from Panama City to Santo Domingo.

How many flights are there a week from Panama City to Santo Domingo?

As of April 2026, there are 80 flights per week flying from Panama City to Santo Domingo.

When is the cheapest time to fly from Panama City to Santo Domingo?

The cheapest month to fly from Panama City to Santo Domingo is usually July.

Which is the cheapest airport to fly into in Santo Domingo?

If you're flying from Panama City, the cheapest airport near Santo Domingo is Santo Domingo Las Americas – which is 23.4 km away from the centre of Santo Domingo. We've found flights into this airport from $803.

Which upcoming date is cheapest to fly from Panama City to Santo Domingo on?

After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Panama City to Santo Domingo on Friday, 3 July 2026.

Can I get a direct flight from Panama City to Santo Domingo?

Yes – the average flight time is 2 hours and 28 minutes.

How can I get the best flight deal from Panama City to Santo Domingo?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Santo Domingo but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Santo Domingo?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Santo Domingo is around 40 days in advance, so don’t leave your flight to the last minute.

What’s the weather like in Santo Domingo?

In April, the average temperature is usually around 27°C. August is typically the warmest month in Santo Domingo, when it usually averages around 31°C. You can expect the least rain in March. The coldest month is January, with temperatures averaging 21°C. The rainiest month is September.

Which is the cheapest airline to fly from Panama City to Santo Domingo with?

The cheapest airline that flies to Santo Domingo is Avianca. And the cheapest airline that flies to Santo Domingo Las Americas Airport is Copa.

Travelling from Panama City to Santo Domingo: what you need to know

There are two main airports you can start your trip from in Panama City. Explore your options departing from Tocumen International Airport (PTY) or Panama Pacifico Airport (BLB) when searching for a flight from Panama City to Santo Domingo.
Touch down in Santo Domingo at Las Americas International Airport (SDQ) or Dr. Joaquin Balaguer International Airport (JBQ).
Take a direct Panama City to Santo Domingo flight and you'll be travelling for an average of 2 hours 30 minutes.
Santo Domingo's timezone is UTC-4, making Santo Domingo one hour ahead of Panama City.
The most popular route for flights from Panama City to Santo Domingo is from Tocumen International Airport (PTY) to Las Americas International Airport (SDQ). There are 29 services every week between these two airports. If you'd like to maximise your time on arrival, the earliest flight from PTY to SDQ is the 07:18 Copa Airlines service. If you prefer to leave later in the day, the last departure is at 23:13 with Copa Airlines.
Give yourself enough time to catch your Panama City to Santo Domingo flight. It's generally best to arrive at least two hours before international departures and an hour ahead for domestic flights.
Travelling during a peak time like June? School holidays and other popular periods can lead to longer lines at security. Play things extra safe and arrive up to four hours ahead of international flights and two hours before a domestic departure.

How to find the cheapest flights from Panama City to Santo Domingo

Book one month before you travel. Research into pricing trends suggests this is the ideal window for finding cheap Panama City to Santo Domingo flights.
Schedule your trip for April. That's the best month for scoring great bargains on plane tickets from Panama City to Santo Domingo. If your travel dates are not set in stone, use the 'Whole month' tool to find the lowest price across every month.
Getting a cheap flight from Panama City to Santo Domingo is a piece of cake with Price Alerts. All you need to do is create one of these automatic alerts and we'll get in touch as soon as the price has dropped.
Tailor your flights using filters. Pick your ideal departure and arrival times, airlines and total journey duration. You can also sort your results by 'Cheapest,' 'Best' or 'Fastest' Panama City to Santo Domingo flights.

Flying from Panama City

Tocumen International Airport (PTY)

If you're searching for a direct flight from Panama City to Santo Domingo, you can depart from Tocumen International Airport (PTY). Travel from PTY to Las Americas International Airport (SDQ) without any stops.
Copa Airlines is a well-known airline that offers direct Panama City to Santo Domingo plane tickets from PTY.
We make it simple to book a Panama City to Santo Domingo flight with a stopover. To see all your options leaving from Tocumen International Airport, deselect 'Direct flights only.' Then, choose a flight with a stop long enough to see the sights of your chosen city. Popular stopovers include:
- Miami International Airport (MIA)
- Luis Munoz Marin International Airport (SJU)
- Reina Beatrix International Airport (AUA)
Located around 18 kilometres from the centre of Panama City, PTY can be reached in about 20 minutes by car (depending on traffic). The journey by public transport is roughly 1 hour 5 minutes.
Want a handy hotel close to Tocumen International Airport? If you're boarding an early flight from Panama City to Santo Domingo, these accommodation options will put you moments from your departure gate:
Tocumen International Airport has an excellent on-time performance, so you're unlikely to face delays. Departures from PTY arrive on schedule 86.03% of the time.

Panama Pacifico Airport (BLB)

Split up your Panama City to Santo Domingo flight with a stop so you can stretch your legs or tick a new place off your list. Some great stopovers between Panama Pacifico Airport and Santo Domingo include:
- El Dorado International Airport (BOG)
- Juan Santamaria International Airport (SJO)
- Rafael Nunez International Airport (CTG)
Driving from central Panama City to BLB typically takes 20 minutes, depending on traffic conditions. It's around 11 kilometres from the city centre to the airport.
You're going on holiday, so why not extend it with an extra night away from home? Consider checking in to one of these accommodation options near Panama Pacifico Airport the day before your flight from Panama City to Santo Domingo:
The majority of flights that leave Panama Pacifico Airport touch down at their destination right on cue. It boasts a strong on-time performance rate of 87%.

Arriving in Santo Domingo

Las Americas International Airport (SDQ)

Las Americas International Airport (SDQ) to central Santo Domingo takes around 30 minutes to reach by car. The centre is roughly 23 kilometres away.
Book a hotel close to SDQ if you have a late flight from Panama City to Santo Domingo. Settle into one of these options and avoid the hassle of a long transfer:
Grab a Las Americas International Airport rental car and discover Santo Domingo and beyond with your own set of wheels. Final Rentals, FlexWays and INFINITY RENT are well-known companies to choose from here.
To get the lowest price, book your ride from Las Americas International Airport about one week in advance of your Panama City to Santo Domingo flight.

Dr. Joaquin Balaguer International Airport (JBQ)

After your flight from Panama City to Santo Domingo has landed, you can get to the city centre in around 25 minutes by car. Central Santo Domingo is roughly 13 kilometres from Dr. Joaquin Balaguer International Airport (JBQ).
Moderno Apartamento Para tu Estancia is a comfortable accommodation option within a short drive of JBQ. Settle in here after your flight from Panama City to Santo Domingo and then hang the 'Do not disturb' sign to get some rest.
Crank up the tunes and hit the open road in a Dr. Joaquin Balaguer International Airport rental car. Collect your wheels from FlexWays and set off on your adventure right away.
Pick the vehicle you actually want, not just whatever's left, by securing your ride from JBQ ahead of time. You'll also avoid paying extra, especially during busy airport times.

Best time to go to Santo Domingo

May is the quietest month for flights from Panama City to Santo Domingo, while January is the busiest. Figure out the best time to visit Santo Domingo based on whether you prefer a laid-back vibe or a lively atmosphere.
The warmest month in Santo Domingo is September, with temperatures ranging between 23ºC and 33ºC. Book your Panama City to Santo Domingo ticket then if that's your definition of good weather.
If you want to travel in cooler conditions, search for a cheap flight from Panama City to Santo Domingo in February when temperatures average between 19ºC and 29ºC.

More about Santo Domingo

Start your Santo Domingo trip off on the right foot by choosing the perfect place to stay. As soon as you've booked your flight from Panama City to Santo Domingo, browse our range of accommodation options including:
There are so many things to see and do in this city it can be hard to figure out where to begin. Alcazar de Colon, National Palace and Basilica Cathedral of Santa Maria la Menor are major attractions which should be on any good Santo Domingo itinerary.

Explore more of Dominican Republic

Santo Domingo Este is just one of the many cities in Dominican Republic waiting to be discovered once you've seen the sights of Santo Domingo. Around 13 kilometres to the east, popular attractions include Museo Las Tres Aves, billeteros Park and Abuela Mota Final Resting Place.
San Pedro de Macorís is another well-known destination in Dominican Republic and is around 64 kilometres east of Santo Domingo. No trip is complete without experiencing El Parquecito, Patrimonio arquitectónico de la ciudad de San Pedro de Macoris and Museo Cultural San Pedro.