Cheap Flights from Knoxville to Chicago from $159

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Flight deals from Knoxville to Chicago

Looking for a cheap last-minute deal or the best return flight from Knoxville Airport to Chicago? If you want to travel next month, return fares start from $167. Find the lowest prices on one-way and return tickets right here.

Chicago.$159 per passenger.Departing Mon, 26 Oct, returning Mon, 2 Nov.Return flight with Allegiant Air.Outbound direct flight with Allegiant Air departs from Knoxville on Mon, 26 Oct, arriving in Chicago Midway.Inbound direct flight with Allegiant Air departs from Chicago Midway on Mon, 2 Nov, arriving in Knoxville.Price includes taxes and charges.From $159, select.

Chicago.$167 per passenger.Departing Thu, 9 Jul, returning Thu, 16 Jul.Return flight with Allegiant Air.Outbound direct flight with Allegiant Air departs from Knoxville on Thu, 9 Jul, arriving in Chicago Midway.Inbound direct flight with Allegiant Air departs from Chicago Midway on Thu, 16 Jul, arriving in Knoxville.Price includes taxes and charges.From $167, select.

Chicago.$172 per passenger.Departing Sun, 2 Aug, returning Sun, 16 Aug.Return flight with Allegiant Air.Outbound direct flight with Allegiant Air departs from Knoxville on Sun, 2 Aug, arriving in Chicago Midway.Inbound direct flight with Allegiant Air departs from Chicago Midway on Sun, 16 Aug, arriving in Knoxville.Price includes taxes and charges.From $172, select.

Chicago.$189 per passenger.Departing Thu, 23 Jul, returning Thu, 6 Aug.Return flight with Allegiant Air.Outbound direct flight with Allegiant Air departs from Knoxville on Thu, 23 Jul, arriving in Chicago Midway.Inbound direct flight with Allegiant Air departs from Chicago Midway on Thu, 6 Aug, arriving in Knoxville.Price includes taxes and charges.From $189, select.

Chicago.$202 per passenger.Departing Thu, 25 Jun, returning Thu, 9 Jul.Return flight with Allegiant Air.Outbound direct flight with Allegiant Air departs from Knoxville on Thu, 25 Jun, arriving in Chicago Midway.Inbound direct flight with Allegiant Air departs from Chicago Midway on Thu, 9 Jul, arriving in Knoxville.Price includes taxes and charges.From $202, select.

Chicago.$218 per passenger.Departing Mon, 5 Oct, returning Fri, 23 Oct.Return flight with Allegiant Air.Outbound direct flight with Allegiant Air departs from Knoxville on Mon, 5 Oct, arriving in Chicago Midway.Inbound direct flight with Allegiant Air departs from Chicago Midway on Fri, 23 Oct, arriving in Knoxville.Price includes taxes and charges.From $218, select.

Chicago.$223 per passenger.Departing Fri, 13 Nov, returning Wed, 25 Nov.Return flight with Allegiant Air.Outbound direct flight with Allegiant Air departs from Knoxville on Fri, 13 Nov, arriving in Chicago Midway.Inbound direct flight with Allegiant Air departs from Chicago Midway on Wed, 25 Nov, arriving in Knoxville.Price includes taxes and charges.From $223, select.

Chicago.$239 per passenger.Departing Thu, 25 Jun, returning Sun, 28 Jun.Return flight with Allegiant Air.Outbound direct flight with Allegiant Air departs from Knoxville on Thu, 25 Jun, arriving in Chicago Midway.Inbound direct flight with Allegiant Air departs from Chicago Midway on Sun, 28 Jun, arriving in Knoxville.Price includes taxes and charges.From $239, select.

Chicago.$419 per passenger.Departing Sun, 30 Aug, returning Thu, 15 Oct.Return flight with United.Outbound direct flight with United departs from Knoxville on Sun, 30 Aug, arriving in Chicago O'Hare International.Inbound direct flight with United departs from Chicago O'Hare International on Thu, 15 Oct, arriving in Knoxville.Price includes taxes and charges.From $419, select.

Chicago.$419 per passenger.Departing Thu, 10 Sep, returning Sun, 13 Sep.Return flight with United.Outbound direct flight with United departs from Knoxville on Thu, 10 Sep, arriving in Chicago O'Hare International.Inbound direct flight with United departs from Chicago O'Hare International on Sun, 13 Sep, arriving in Knoxville.Price includes taxes and charges.From $419, select.

Chicago.$419 per passenger.Departing Tue, 5 Jan, returning Tue, 19 Jan.Return flight with United.Outbound direct flight with United departs from Knoxville on Tue, 5 Jan, arriving in Chicago O'Hare International.Inbound direct flight with United departs from Chicago O'Hare International on Tue, 19 Jan, arriving in Knoxville.Price includes taxes and charges.From $419, select.

Chicago.$420 per passenger.Departing Thu, 24 Sep, returning Thu, 1 Oct.Return flight with United.Outbound direct flight with United departs from Knoxville on Thu, 24 Sep, arriving in Chicago O'Hare International.Inbound direct flight with United departs from Chicago O'Hare International on Thu, 1 Oct, arriving in Knoxville.Price includes taxes and charges.From $420, select.

Chicago.$420 per passenger.Departing Mon, 31 Aug, returning Mon, 7 Sep.Return flight with United.Outbound direct flight with United departs from Knoxville on Mon, 31 Aug, arriving in Chicago O'Hare International.Inbound direct flight with United departs from Chicago O'Hare International on Mon, 7 Sep, arriving in Knoxville.Price includes taxes and charges.From $420, select.

Chicago.$523 per passenger.Departing Tue, 29 Dec, returning Tue, 12 Jan.Return flight with United.Outbound direct flight with United departs from Knoxville on Tue, 29 Dec, arriving in Chicago O'Hare International.Inbound direct flight with United departs from Chicago O'Hare International on Tue, 12 Jan, arriving in Knoxville.Price includes taxes and charges.From $523, select.

Chicago.$656 per passenger.Departing Mon, 22 Feb, returning Fri, 26 Feb.Return flight with Delta.Outbound indirect flight with Delta, departs from Knoxville on Mon, 22 Feb, arriving in Chicago O'Hare International.Inbound indirect flight with Delta, departs from Chicago O'Hare International on Fri, 26 Feb, arriving in Knoxville.Price includes taxes and charges.From $656, select.

Chicago.$703 per passenger.Departing Tue, 1 Dec, returning Fri, 4 Dec.Return flight with United.Outbound direct flight with United departs from Knoxville on Tue, 1 Dec, arriving in Chicago O'Hare International.Inbound direct flight with United departs from Chicago O'Hare International on Fri, 4 Dec, arriving in Knoxville.Price includes taxes and charges.From $703, select.

Find the cheapest month to fly from Knoxville to Chicago

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Knoxville to Chicago flights are currently cheapest in July.

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Direct flights from Knoxville to Chicago

Alternative Knoxville to Chicago routes

Looking for the cheapest, fastest or easiest route from Knoxville to Chicago? You could fly into the following airports instead.

Knoxville to Chicago: Flight information

The things to know before you go.

Cheapest flight found	$159
Cheapest month to fly	October
Average flight time	1 hr, 51 mins
Most popular airline	American Airlines
Average flights per week	403

Finding cheap flights from Knoxville to Chicago: Frequently asked questions

How many airports are there in Chicago?

There are 4 airports in Chicago: Chicago Midway, Chicago O'Hare International, Chicago Dupage County, and Chicago Rockford.

How much are return flights from Knoxville to Chicago?

The best price we found for a return flight from Knoxville to Chicago is $159. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

How long does it take to fly from Knoxville to Chicago?

1 hour and 50 minutes is the average flight time from Knoxville to Chicago.

Which airlines fly direct from Knoxville to Chicago?

American Airlines, United and SkyWest Airlines fly direct from Knoxville to Chicago.

How many flights are there a week from Knoxville to Chicago?

As of June 2026, there are 403 flights per week flying from Knoxville to Chicago.

When is the cheapest time to fly from Knoxville to Chicago?

The cheapest month to fly from Knoxville to Chicago is usually October.

Which is the cheapest airport to fly into in Chicago?

If you're flying from Knoxville Airport, the cheapest airport near Chicago is Chicago Midway – which is 14.5 km away from the centre of Chicago. We've found flights into this airport from $159.

Which upcoming date is cheapest to fly from Knoxville Airport to Chicago on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Knoxville Airport to Chicago on Monday, 26 October 2026.

Can I get a direct flight from Knoxville Airport to Chicago?

Yes – the average flight time is 1 hour and 50 minutes.

How can I get the best flight deal from Knoxville Airport to Chicago?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Chicago but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Chicago?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Chicago is around 40 days in advance, so don’t leave your flight to the last minute.

What’s the weather like in Chicago?

In June, the average temperature is usually around 19°C. July is typically the warmest month in Chicago, when it usually averages around 26°C. You can expect the least rain in January. The coldest month is January, with temperatures averaging -8°C. The rainiest month is August.

Which is the cheapest airline to fly from Knoxville Airport to Chicago with?

Currently, Allegiant Air offers the cheapest flight tickets to Chicago.

Travelling from Knoxville McGhee Tyson Airport (TYS) to Chicago: what you need to know

The average length of a direct flight from Knoxville McGhee Tyson Airport to Chicago is 1 hour 45 minutes.
The timezone in Chicago is UTC-6. The city is one hour behind Knoxville, where Knoxville McGhee Tyson Airport is located.
With 53 weekly flights between the two airports, Knoxville McGhee Tyson Airport (TYS) to Chicago O'Hare International Airport (ORD) is the busiest route. American Airlines operates the earliest flight at 05:15. If you're eager to get more out of your day before you fly, the last flight from TYS to ORD is with American Airlines at 20:20.
For a relaxed start to your TYS to Chicago flight, leave plenty of time to check in and drop off your luggage. Arriving two hours before international departures and one hour before domestic flights is the general rule.
During popular months like June, it's wise to get to the airport earlier than usual. Plan to arrive two hours before domestic departures and four hours ahead of an international flight whenever you're flying during a peak period in general.
You can book a direct Knoxville McGhee Tyson Airport to Chicago ticket. Start your journey at TYS and touch down at Chicago O'Hare International Airport (ORD).
There's a good selection of airlines operating direct flights from Knoxville McGhee Tyson Airport to Chicago, including:
Located around 18 kilometres from central Knoxville, TYS can be reached in about 25 minutes by car, depending on traffic. Travelling on public transport will take roughly 50 minutes.
Booked an early flight from Knoxville McGhee Tyson Airport to Chicago? Avoid the last-minute rush to the terminal (and enjoy a little extra shut-eye) by choosing one of these stays near TYS:
Of all flights leaving Knoxville McGhee Tyson Airport, 76% land on time at their destination.
TYS is located at 2055 Alcoa Highway.

How to find the cheapest flights from Knoxville McGhee Tyson Airport (TYS) to Chicago

$66 is the cheapest price we've seen for a one-way Knoxville McGhee Tyson Airport to Chicago flight. A return ticket right now is $159. Depending on when and how early you book, these fares may change.
Don't leave everything to the last minute. You're more likely to land cheap flights from TYS to Chicago if you book in advance. Airlines often have some great early bird deals.
The 'Whole month' tool will show you the cheapest tickets from Knoxville McGhee Tyson Airport to Chicago throughout the month. It's an easy way to snap up a bargain if your plans aren't set in stone.
Stay on top of deals for cheap flights from TYS to Chicago by setting up a Price Alert. We'll send you an email or notification through the app when a new low fare is offered.
Select your preferred arrival and departure times, number of stops and airlines with our filters. Then, sort the results for your flight from Knoxville McGhee Tyson Airport to Chicago by 'Fastest,' 'Cheapest' or 'Best.'

Airports in Chicago

Chicago O'Hare International Airport (ORD)

Chicago O'Hare International Airport (ORD) is around 27 kilometres from the centre of Chicago. If you're getting a taxi or a ride-share, the drive takes about 30 minutes.
When travelling by public transport, expect a journey time of around 45 minutes.
If you're arriving on a late flight from Knoxville McGhee Tyson Airport to Chicago, nothing beats the convenience of staying near the terminal. Grab your suitcases from the carousel and then be showered and snoozing not long after at one of these hotels near ORD:
Reserving your ride from Chicago O'Hare International Airport about four weeks ahead of your flight from TYS to Chicago can help you secure the lowest rate.
ORD is located at 10000 West O'Hare.

Chicago Midway International Airport (MDW)

Chicago Midway International Airport (MDW) is roughly 16 kilometres from the centre of Chicago. Following your flight from Knoxville McGhee Tyson Airport to Chicago, it'll take you around 25 minutes to get to the heart of the city in a taxi or ride-share.
You can expect the journey to take about 30 minutes on public transport.
After stepping off your TYS to Chicago flight, unwind at a hotel close to MDW. These are some comfortable accommodation options that'll help you get into relaxation mode:
Avoid potential price surges. Booking your ride four weeks ahead of your arrival at MDW will save you money.
The address for Chicago Midway International Airport is 5700 South Cicero.

Chicago Rockford International Airport (RFD)

Find your way to the city centre after your flight from Knoxville McGhee Tyson Airport to Chicago has arrived. Central Chicago is about 145 kilometres from Chicago Rockford International Airport (RFD) and takes roughly 1 hour 40 minutes to reach by taxi or ride-share.
The journey takes around 2 hours by public transport.
Find a hotel close to RFD and get from baggage claim to your bed in a snap. Whether you're coming in on a late TYS to Chicago flight or just want to simplify your travel plans, these accommodation options will have you settling in quickly:
If you prefer a specific model or make, booking early increases your chances of getting exactly what you want. Book your ride from RFD a couple of weeks ahead of your flight from Knoxville McGhee Tyson Airport to Chicago.
Chicago Rockford International Airport can be found at 2 Airport Cir.

Best time to go to Chicago

July is the most popular month for flights from Knoxville McGhee Tyson Airport to Chicago. To escape the crowds, plan your trip to Chicago in January.
Lock in a Knoxville McGhee Tyson Airport to Chicago plane ticket with a departure in July if you want to experience the city during its warmest month. You can expect temperatures to range from 16ºC to 28ºC.
Search for cheap tickets from TYS to Chicago in January if you'd rather travel during cooler conditions. Temperatures are at their lowest then, ranging between -12ºC and 3ºC on average.

More about Chicago

When it comes to searching for somewhere to lay your head, you'll find the best places to stay in Chicago right here. Explore these hotels after you've booked your flight from Knoxville McGhee Tyson Airport to Chicago:
There are so many things to do and see in this city it can be tricky to know where to begin. Art Institute of Chicago, Millennium Park and Willis Tower are top sights which should feature on every Chicago itinerary.

Explore more of the United States

Chicago has plenty to offer, but there are so many other parts of the United States waiting to be discovered. About 451 kilometres southeast of Chicago, a visit to Columbus will keep your itinerary packed. Start with attractions like Franklin Park Conservatory and Botanical Gardens, Whetstone Park / Park of Roses and Ohio Theatre.
If you're ready to explore another side of the United States, consider Indianapolis, about 257 kilometres southeast of Chicago. Lucas Oil Stadium, Eiteljorg Museum and The Children's Museum of Indianapolis are key reasons to visit.