Cheap Flights from Syracuse to Des Moines

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Find the cheapest month or even day of the year to fly to Des Moines

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Flight deals from Syracuse to Des Moines

Looking for a cheap last-minute deal or the best return flight from Syracuse Airport to Des Moines Airport? If you want to travel next month, return fares start from $548. Find the lowest prices on one-way and return tickets right here.

Des Moines.$550 per passenger.Departing Fri, 21 Aug, returning Sun, 23 Aug.Return flight with Delta.Outbound indirect flight with Delta, departs from Syracuse on Fri, 21 Aug, arriving in Des Moines.Inbound indirect flight with Delta, departs from Des Moines on Sun, 23 Aug, arriving in Syracuse.Price includes taxes and charges.From $550, select.

Des Moines.$551 per passenger.Departing Sat, 18 Jul, returning Sat, 25 Jul.Return flight with Delta.Outbound indirect flight with Delta, departs from Syracuse on Sat, 18 Jul, arriving in Des Moines.Inbound indirect flight with Delta, departs from Des Moines on Sat, 25 Jul, arriving in Syracuse.Price includes taxes and charges.From $551, select.

Des Moines.$1,051 per passenger.Departing Mon, 12 Apr, returning Wed, 14 Apr.Return flight with Delta.Outbound indirect flight with Delta, departs from Syracuse on Mon, 12 Apr, arriving in Des Moines.Inbound indirect flight with Delta, departs from Des Moines on Wed, 14 Apr, arriving in Syracuse.Price includes taxes and charges.From $1,051, select.

Des Moines.$1,051 per passenger.Departing Mon, 1 Mar, returning Wed, 3 Mar.Return flight with Delta.Outbound indirect flight with Delta, departs from Syracuse on Mon, 1 Mar, arriving in Des Moines.Inbound indirect flight with Delta, departs from Des Moines on Wed, 3 Mar, arriving in Syracuse.Price includes taxes and charges.From $1,051, select.

Des Moines.$1,051 per passenger.Departing Mon, 9 Nov, returning Wed, 11 Nov.Return flight with Delta.Outbound indirect flight with Delta, departs from Syracuse on Mon, 9 Nov, arriving in Des Moines.Inbound indirect flight with Delta, departs from Des Moines on Wed, 11 Nov, arriving in Syracuse.Price includes taxes and charges.From $1,051, select.

Des Moines.$1,051 per passenger.Departing Mon, 14 Sep, returning Wed, 16 Sep.Return flight with Delta.Outbound indirect flight with Delta, departs from Syracuse on Mon, 14 Sep, arriving in Des Moines.Inbound indirect flight with Delta, departs from Des Moines on Wed, 16 Sep, arriving in Syracuse.Price includes taxes and charges.From $1,051, select.

Find the cheapest month to fly from Syracuse to Des Moines

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Syracuse to Des Moines flights are currently cheapest in August.

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Syracuse to Des Moines: Alternative routes

Compare routes from Syracuse to Des Moines below. You may find an airport to fly into that's cheaper, faster, or easier than Des Moines.

Des Moines

8km from central Des Moines

ClosestCheapest

from $550

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Syracuse to Des Moines: Flight information

The things to know before you go.

Cheapest flight found	$550
Cheapest month to fly	August

Finding cheap flights from Syracuse to Des Moines: Frequently asked questions

How much are return flights from Syracuse to Des Moines?

The best price we found for a return flight from Syracuse to Des Moines is $548. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

Which airlines fly direct from Syracuse to Des Moines?

Currently, there are no airlines that fly direct from Syracuse to Des Moines. But we found flights with one or more stops from $550.

How many flights are there a week from Syracuse to Des Moines?

As of June 2026, there are no flights flying from Syracuse to Des Moines.

When is the cheapest time to fly from Syracuse to Des Moines?

The cheapest month to fly from Syracuse to Des Moines is usually August.

Which upcoming date is cheapest to fly from Syracuse Airport to Des Moines Airport on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Syracuse Airport to Des Moines Airport on Friday, 21 August 2026.

Can I get a direct flight from Syracuse Airport to Des Moines Airport?

No airlines currently offer direct flights between Syracuse Airport and Des Moines Airport. Most routes have one or more stops.

How can I find the best flight deal to Des Moines?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Des Moines but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Des Moines?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Des Moines is around 40 days in advance, so don’t leave your flight to the last minute.

Which is the cheapest airline to fly from Syracuse Airport to Des Moines with?

Currently, Delta offers the cheapest flight tickets to Des Moines.

Travelling from Syracuse Airport (SYR) to Des Moines Airport (DSM): what you need to know

Arriving two hours before an international flight and one hour ahead of a domestic departure are golden rules for hassle-free flying. Make sure you're at the airport on time to board your SYR to DSM flight.
Travelling during a peak time like August? Major public holidays and other popular seasons can result in longer queues and delays at security. Play things extra safe and arrive up to four hours ahead of an international flight and two hours before a domestic departure.
We make it a breeze to book a flight with a stopover. To see your options for tickets from Syracuse Airport to Des Moines Airport, uncheck 'Direct flights only.' Then, choose a flight offering a stop long enough to visit your chosen city. Popular stopovers between SYR and DSM include:
- Chicago O'Hare International Airport
- Detroit Wayne County Airport
- Minneapolis St Paul Airport

How to find the cheapest flights from Syracuse Airport (SYR) to Des Moines Airport (DSM)

The cheapest price we've found for a one-way Syracuse Airport to Des Moines Airport flight is $522. A round-trip fare is currently $550. Depending on the availability when you book, these fares may change.
It's usually best to book early if you're looking for cheap tickets from SYR to DSM. That's because airlines adjust prices based on demand, which tends to rise closer to departure.
The 'Whole month' search tool shows you the cheapest flights from Syracuse Airport to Des Moines Airport across the month. It's an easy way to snap up a bargain if your travel plans aren't set in stone.
Cut down on the time spent looking for cheap flights from SYR to DSM by setting up a Price Alert. We'll send you an email or notification on the app when a lower fare pops up.
Tailor your trip using filters. Pick your arrival and departure times, airlines and total journey duration. You can also sort results by 'Best,' 'Fastest' or 'Cheapest' flights from Syracuse Airport to Des Moines Airport.

Handy information about Syracuse Airport (SYR)

SYR is located at City Hall.
71% of flights departing from Syracuse Airport land at their destination on schedule.
To get to Syracuse Airport from central Syracuse, it takes around 20 minutes if you're planning to drive. This depends on traffic, however. It's approximately 11 kilometres from the airport to the city centre.
The trip when using public transport takes about 35 minutes.
Get your holiday off to a relaxed start by staying near SYR. Whether you've booked an early flight from Syracuse Airport to Des Moines Airport or just don't like being rushed, these hotels are ideal:

Arriving at Des Moines Airport (DSM)

If you're landing on a late Syracuse Airport to Des Moines Airport flight, few things top the convenience of staying near the terminal. Grab your suitcases from the carousel and then be showered and relaxing shortly after at one of these hotels near DSM:
Say yes to new adventures by picking up a Des Moines Airport rental car. Grab a set of wheels from Hertz, Enterprise or Alamo to explore Des Moines and beyond.
Increase your chances of getting a great price by booking as soon as possible. Reserving your vehicle from Des Moines Airport at least a couple of weeks in advance is a good idea.

Getting from Des Moines Airport (DSM) to central Des Moines

You'll find DSM at 5800 Fleur Drive, Suite 201.
Des Moines Airport to central Des Moines has a drive time of about 15 minutes. It's approximately 11 kilometres away.
Travelling on public transport will take you around 30 minutes.

When to fly to Des Moines Airport (DSM)

It's time to work out your trip dates for your flight from Syracuse Airport to Des Moines Airport. August is the busiest month to head to Des Moines. If you'd like a quieter vibe, go in March.
Lock in your flight from Syracuse Airport to Des Moines Airport for July if you'd like to go to Des Moines during its warmest month. You can expect temperatures of between 15ºC and 31ºC.
If you like cooler conditions, look for a cheap ticket from SYR to DSM in January. Temperatures average between -13ºC and 2ºC then.

Explore more of the United States

You've seen Des Moines, now it's time to explore more of the United States. Travel around 499 kilometres east to Chicago to check off its top sights. From Millennium Park to Art Institute of Chicago and Willis Tower, there's plenty to keep you on the go.
If you want to check out another major destination in the United States, consider Milwaukee, about 499 kilometres east of Des Moines. Richards Duplex Apartments by Frank Lloyd Wright, Miller Park and Milwaukee County Zoo are among the biggest draws.