Cheap Flights from Guayaquil to Panama City from $430

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Flight deals from Guayaquil to Panama City

Looking for a cheap last-minute deal or the best return flight from Guayaquil Airport to Panama City? If you want to travel next month, return fares start from $434. Find the lowest prices on one-way and return tickets right here.

Panama City.$430 per passenger.Departing Sun, 7 Jun, returning Mon, 8 Jun.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Guayaquil on Sun, 7 Jun, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 8 Jun, arriving in Guayaquil.Price includes taxes and charges.From $430, select.

Panama City.$434 per passenger.Departing Sat, 25 Jul, returning Wed, 29 Jul.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Guayaquil on Sat, 25 Jul, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Wed, 29 Jul, arriving in Guayaquil.Price includes taxes and charges.From $434, select.

Panama City.$434 per passenger.Departing Sat, 30 May, returning Wed, 3 Jun.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Guayaquil on Sat, 30 May, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Wed, 3 Jun, arriving in Guayaquil.Price includes taxes and charges.From $434, select.

Panama City.$434 per passenger.Departing Sun, 28 Jun, returning Thu, 2 Jul.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Guayaquil on Sun, 28 Jun, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Thu, 2 Jul, arriving in Guayaquil.Price includes taxes and charges.From $434, select.

Panama City.$434 per passenger.Departing Thu, 27 Aug, returning Sun, 30 Aug.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Guayaquil on Thu, 27 Aug, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Sun, 30 Aug, arriving in Guayaquil.Price includes taxes and charges.From $434, select.

Panama City.$434 per passenger.Departing Wed, 6 May, returning Fri, 8 May.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Guayaquil on Wed, 6 May, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 8 May, arriving in Guayaquil.Price includes taxes and charges.From $434, select.

Panama City.$434 per passenger.Departing Wed, 29 Jul, returning Tue, 18 Aug.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Guayaquil on Wed, 29 Jul, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Tue, 18 Aug, arriving in Guayaquil.Price includes taxes and charges.From $434, select.

Panama City.$434 per passenger.Departing Mon, 7 Sep, returning Thu, 10 Sep.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Guayaquil on Mon, 7 Sep, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Thu, 10 Sep, arriving in Guayaquil.Price includes taxes and charges.From $434, select.

Panama City.$436 per passenger.Departing Fri, 29 May, returning Thu, 16 Jul.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Guayaquil on Fri, 29 May, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Thu, 16 Jul, arriving in Guayaquil.Price includes taxes and charges.From $436, select.

Panama City.$436 per passenger.Departing Sat, 30 May, returning Mon, 24 Aug.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Guayaquil on Sat, 30 May, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 24 Aug, arriving in Guayaquil.Price includes taxes and charges.From $436, select.

Panama City.$453 per passenger.Departing Mon, 31 Aug, returning Sat, 5 Sep.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Guayaquil on Mon, 31 Aug, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Sat, 5 Sep, arriving in Guayaquil.Price includes taxes and charges.From $453, select.

Panama City.$468 per passenger.Departing Mon, 3 Aug, returning Thu, 6 Aug.Return flight with Copa.Outbound direct flight with Copa departs from Guayaquil on Mon, 3 Aug, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Thu, 6 Aug, arriving in Guayaquil.Price includes taxes and charges.From $468, select.

Panama City.$468 per passenger.Departing Wed, 6 May, returning Fri, 8 May.Return flight with Copa.Outbound direct flight with Copa departs from Guayaquil on Wed, 6 May, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Fri, 8 May, arriving in Guayaquil.Price includes taxes and charges.From $468, select.

Panama City.$468 per passenger.Departing Sun, 28 Jun, returning Thu, 2 Jul.Return flight with Copa.Outbound direct flight with Copa departs from Guayaquil on Sun, 28 Jun, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Thu, 2 Jul, arriving in Guayaquil.Price includes taxes and charges.From $468, select.

Panama City.$468 per passenger.Departing Thu, 28 May, returning Mon, 1 Jun.Return flight with Copa.Outbound direct flight with Copa departs from Guayaquil on Thu, 28 May, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Mon, 1 Jun, arriving in Guayaquil.Price includes taxes and charges.From $468, select.

Panama City.$468 per passenger.Departing Mon, 1 Jun, returning Sat, 6 Jun.Return flight with Copa.Outbound direct flight with Copa departs from Guayaquil on Mon, 1 Jun, arriving in Panama City Tocumen International.Inbound direct flight with Copa departs from Panama City Tocumen International on Sat, 6 Jun, arriving in Guayaquil.Price includes taxes and charges.From $468, select.

Find the cheapest month to fly from Guayaquil to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Guayaquil to Panama City flights are currently cheapest in June.

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Direct flights from Guayaquil to Panama City

Alternative Guayaquil to Panama City routes

Looking for the cheapest, fastest or easiest route from Guayaquil to Panama City? You could fly into the following airports instead.

Guayaquil to Panama City: Flight information

The things to know before you go.

Cheapest flight found	$430
Cheapest month to fly	June
Average flight time	2 hrs, 12 mins
Most popular airline	Copa
Average flights per week	318

Finding cheap flights from Guayaquil to Panama City: Frequently asked questions

How many airports are there in Panama City?

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.

How much are return flights from Guayaquil to Panama City?

The best price we found for a return flight from Guayaquil to Panama City is $430. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

How long does it take to fly from Guayaquil to Panama City?

2 hours and 12 minutes is the average flight time from Guayaquil to Panama City.

Which airlines fly direct from Guayaquil to Panama City?

Copa, KLM and United fly direct from Guayaquil to Panama City.

How many flights are there a week from Guayaquil to Panama City?

As of April 2026, there are 318 flights per week flying from Guayaquil to Panama City.

When is the cheapest time to fly from Guayaquil to Panama City?

The cheapest month to fly from Guayaquil to Panama City is usually June.

Which is the cheapest airport to fly into in Panama City?

If you're flying from Guayaquil Airport, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the centre of Panama City. We've found flights into this airport from $430.

Which upcoming date is cheapest to fly from Guayaquil Airport to Panama City on?

After crunching the numbers on our flight calendar, we found that it's currently cheapest to fly from Guayaquil Airport to Panama City on Sunday, 7 June 2026.

Can I get a direct flight from Guayaquil Airport to Panama City?

Yes – the average flight time is 2 hours and 12 minutes.

How can I get the best flight deal from Guayaquil Airport to Panama City?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Panama City?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.

What’s the weather like in Panama City?

In April, the average temperature is usually around 28°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.

Which is the cheapest airline to fly from Guayaquil Airport to Panama City with?

Currently, Avianca and Copa offer the cheapest flight tickets to Panama City.

Travelling from Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE) to Panama City: what you need to know

Jump on a direct flight from Guayaquil Jose Joaquin de Olmedo Intl Airport to Panama City and you'll be travelling for around 2 hours 15 minutes.
Panama City and Guayaquil (where Guayaquil Jose Joaquin de Olmedo Intl Airport is located) are both in the UTC-5 timezone. This means you won't have to adjust your watch after you land.
With 39 flights a week between the two airports, Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE) to Panama City Tocumen International Airport (PTY) is the busiest route. Copa Airlines operates the earliest flight at 04:26. If you prefer to get more out of your day before flying, the latest departure from GYE to PTY is with Copa Airlines at 18:49.
Leave plenty of time to catch your GYE to Panama City flight. Generally, it's best to arrive two hours before international departures and an hour ahead for domestic flights.
Flying during a peak month such as July? Public holidays and other high seasons can lead to longer queues at security. Be extra cautious and arrive up to four hours ahead of international flights and two hours before a domestic departure.
Direct Guayaquil Jose Joaquin de Olmedo Intl Airport to Panama City tickets are available for booking. Panama City Tocumen International Airport (PTY) is where you'll step off the plane.
Book your seat with Copa Airlines. This popular carrier operates direct flights from Guayaquil Jose Joaquin de Olmedo Intl Airport to Panama City.
We make it a breeze to book plane tickets from GYE to Panama City with a stopover. To see your options, deselect 'Direct flights only.' Next, select a flight with a stop long enough to explore the city of your choice. Some popular stopovers include:
- Bogota El Dorado International Airport (BOG)
- Lima Jorge Chavez International Airport (LIM)
- Quito Mariscal Sucre International Airport (UIO)
Travelling from central Guayaquil to GYE takes about 35 minutes by public transport. If you ride-share, drive or take a taxi, you'll cover the 5 kilometres in 20 minutes or so, depending on traffic conditions.
Planning to catch an early flight from Guayaquil Jose Joaquin de Olmedo Intl Airport to Panama City? Avoid the last-minute rush to the terminal (and get some extra shut-eye) by choosing one of these hotels close to GYE:
90% of flights leaving Guayaquil Jose Joaquin de Olmedo Intl Airport arrive at their destination as planned. With its strong on-time stats, you're unlikely to face delays when setting off from GYE.

How to find the cheapest flights from Guayaquil Jose Joaquin de Olmedo Intl Airport (GYE) to Panama City

$211 is currently the lowest price for a one-way Guayaquil Jose Joaquin de Olmedo Intl Airport to Panama City flight. Return plane tickets start from $430. These fares may change depending on availability.
To pick up cheap flights from GYE to Panama City, book in advance. Airlines tend to offer lower fares when tickets are first released.
The 'Whole month' tool will show you the cheapest tickets from Guayaquil Jose Joaquin de Olmedo Intl Airport to Panama City across every month. It's a good way to find a bargain if your dates aren't set in stone.
You don't need to keep looking every day to see if fares have dropped when you create a Price Alert. We'll notify you when there's an updated deal for cheap flights from GYE to Panama City.
Tailor your flights with filters. Select your preferred arrival and departure times, total journey duration and airlines. You can also sort results by 'Best,' 'Cheapest' or 'Fastest' flights from Guayaquil Jose Joaquin de Olmedo Intl Airport to Panama City.

Airports in Panama City

Panama City Tocumen International Airport (PTY)

Panama City Tocumen International Airport (PTY) to central Panama City takes about 35 minutes by car. The centre is roughly 24 kilometres away.
Getting there by public transport takes about 50 minutes.
The last thing you want is a long journey to your hotel if you're arriving on a late flight from Guayaquil Jose Joaquin de Olmedo Intl Airport to Panama City. Book one of these accommodation options near PTY instead:
Reserving your vehicle from Panama City Tocumen International Airport about three weeks ahead of your flight from GYE to Panama City can help you secure the lowest rate.

Panama Pacifico International Airport (BLB)

Once your flight from Guayaquil Jose Joaquin de Olmedo Intl Airport to Panama City has hit the tarmac, you can make your way to the city centre in about 10 minutes by car. Central Panama City is roughly 6 kilometres from Panama Pacifico International Airport (BLB).
If you choose to travel on public transport, you'll reach the centre in 20 minutes or so.
You'll find some comfortable places to rest your head close to BLB. Unwind and get cosy after your GYE to Panama City flight at any of these perfectly located options:
Get exactly what you want. Securing your ride from BLB one week in advance often means more savings and a bigger choice of vehicles.

Best time to go to Panama City

January is the most popular month for flights from Guayaquil Jose Joaquin de Olmedo Intl Airport to Panama City. To steer clear of the crowds, head to Panama City in September.
Book a Guayaquil Jose Joaquin de Olmedo Intl Airport to Panama City plane ticket with a departure in March if you're eager to explore the city during its warmest month. Expect temperatures to range from 21ºC to 32ºC.
Search for cheap tickets from GYE to Panama City in January if you'd rather travel during cooler conditions. Temperatures are at their lowest then, ranging between 22ºC and 31ºC on average.

More about Panama City

When it comes to looking for somewhere to rest your head, you'll find the best stays in Panama City right here. Explore these hotels once you've locked in your flight from Guayaquil Jose Joaquin de Olmedo Intl Airport to Panama City:
All great holidays should include a little sightseeing. Metropolitan Cathedral (Catedral Metropolitan), Casco Viejo and Independence Square are must-do's during your Panama City adventure.

Explore more of Panama

You've done Panama City, now it's time to discover other corners of Panama. Travel about 322 kilometres west to David to tick off its top attractions. From Museo Antropológico y Etnográfico Dr. Roberto De La Guardia to Raptors To The Rescue and Unachi Botanical garden, you'll have a full itinerary ahead.
Time for another stop? Head for Santiago de Veraguas. It's located about 193 kilometres southwest of Panama City and is known for highlights like Santiago the Apostle Cathedral, Santiago de Veraguas.