Flights from Panama City to Santa Cruz Department

Flight deals from Panama City to Santa Cruz Department

Looking for a cheap last-minute deal or the best return flight from Panama City to Santa Cruz Department? If you want to travel next month, return fares start from $805. Find the lowest prices on one-way and return tickets right here.

Flying from Panama City to Santa Cruz Department

Arm yourself with these facts on the fly.
Cheapest flight found$805
Cheapest month to flyJune
Average flight time4 hrs, 59 mins
Cheapest airport to fly fromPanama City Tocumen International
Most popular airlineCopa

Frequently asked questions

We looked at all of the upcoming return flights from Panama City to Santa Cruz Department we could find over the next 12 months. It looks like $805 is the best price. This is good, compared to the average Santa Cruz Department ticket price of $805.
The cheapest month to fly from Panama City to Santa Cruz Department is currently June.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Panama City to Santa Cruz Department on Sunday, 21 June 2026.
Panama City Tocumen International Airport offers direct flights to Santa Cruz Department.
If you're flying from Panama City, the cheapest city in Santa Cruz Department to fly into is Santa Cruz. The cheapest airport serving Santa Cruz at the moment is Santa Cruz Viru Viru.
The average flight time between Panama City and Santa Cruz Department is 4 hours and 59 minutes.